Abstract
While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.
Original language | English |
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Pages (from-to) | 274-286 |
Number of pages | 13 |
Journal | European journal of heart failure |
Volume | 24 |
Issue number | 2 |
Early online date | 3 Nov 2021 |
DOIs | |
Publication status | Published - Feb 2022 |
Keywords
- Takotsubo syndrome
- Pathophysiology
- Vascular
- Nervous system
- Oestrogen
- Genetics
- microRNA
- Inducible pluripotent stem cell models
- TAKO-TSUBO CARDIOMYOPATHY
- STRESS-INDUCED CARDIOMYOPATHY
- COUPLED RECEPTOR KINASE-5
- NERVOUS-SYSTEM
- DIAGNOSTIC-CRITERIA
- EMOTIONAL-STRESS
- MODEL REVEALS
- FOLLOW-UP
- RAT MODEL
- CATECHOLAMINE