Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

E. Omerovic*, R. Citro, E. Bossone, B. Redfors, J. Backs, B. Bruns, M. Ciccarelli, L.S. Couch, D. Dawson, G. Grassi, M. Iacoviello, G. Parodi, B. Schneider, C. Templin, J.R. Ghadri, T. Thum, O. Chioncel, C.G. Tocchetti, J. Van der Velden, S. HeymansA.R. Lyon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)

Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.
Original languageEnglish
Pages (from-to)274-286
Number of pages13
JournalEuropean journal of heart failure
Volume24
Issue number2
Early online date3 Nov 2021
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Takotsubo syndrome
  • Pathophysiology
  • Vascular
  • Nervous system
  • Oestrogen
  • Genetics
  • microRNA
  • Inducible pluripotent stem cell models
  • TAKO-TSUBO CARDIOMYOPATHY
  • STRESS-INDUCED CARDIOMYOPATHY
  • COUPLED RECEPTOR KINASE-5
  • NERVOUS-SYSTEM
  • DIAGNOSTIC-CRITERIA
  • EMOTIONAL-STRESS
  • MODEL REVEALS
  • FOLLOW-UP
  • RAT MODEL
  • CATECHOLAMINE

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