Paternal impact on genetic integrity in newborns.

J.O. Linschooten

    Research output: ThesisDoctoral ThesisInternal

    356 Downloads (Pure)

    Abstract

    The quality of the DNA in sperm from potential fathers is under constant pressure because it is exposed to a great diversity of harmful substances. This can lead to transmission of DNA damage to the offspring with long-lasting health consequences. The research for this dissertation shows that a lifestyle with bad habits, such as smoking, has indeed a harmful effect on the DNA in the sperm. Even more important is that subsequently an indication was found for genetic effects of this damage in the offspring.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • van Schooten, Frederik, Supervisor
    • Godschalk, Roger, Advisor
    Award date20 Jun 2012
    Place of PublicationMaastricht
    Publisher
    Print ISBNs9789088914362
    Publication statusPublished - 1 Jan 2012

    Keywords

    • DNA
    • sperm
    • health

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