The quality of the DNA in sperm from potential fathers is under constant pressure because it is exposed to a great diversity of harmful substances. This can lead to transmission of DNA damage to the offspring with long-lasting health consequences. The research for this dissertation shows that a lifestyle with bad habits, such as smoking, has indeed a harmful effect on the DNA in the sperm. Even more important is that subsequently an indication was found for genetic effects of this damage in the offspring.
|Qualification||Doctor of Philosophy|
|Award date||20 Jun 2012|
|Place of Publication||Maastricht|
|Publication status||Published - 1 Jan 2012|