Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

Felix Barajas Ordonez; Denise Wolleschak; Yannic Zeller; Mattes Hinnerichs; Pablo Rodríguez-Feria; Anar Aghayev; Martin Mikusko; Jan Borggrefe; Dimitrios Mougiakakos; Alexey Surov

doi:10.1080/10428194.2024.2319226

Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

Felix Barajas Ordonez^*, Denise Wolleschak, Yannic Zeller, Mattes Hinnerichs, Pablo Rodríguez-Feria, Anar Aghayev, Martin Mikusko, Jan Borggrefe, Dimitrios Mougiakakos, Alexey Surov

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Studies regarding the influence of body composition parameters as predictors on overall survival (OS) in patients with multiple myeloma (MM) are scarce. OS and progression-free survival (PFS) were retrospectively assessed in 129 patients with MM undergoing autologous stem cell transplantation (ASCT) after a follow-up of 2?years. A computed tomography (CT) based semi-automated assessment of body composition was performed. No statistically significant differences were noted in 2-year OS, PFS, or post-transplant adverse events in the body composition groups of subcutaneous adipose tissue (SAT) (low vs. high-SAT), visceral adipose tissue (VAT) (low vs. high-VAT), visceral-to-subcutaneous fat ratio (VSR) (low vs. high VSR), and sarcopenia in terms of skeletal muscle index (SMI) (non-sarcopenic vs. sarcopenic). In conclusion, adipose and muscle tissue do not limit OS or affect the PFS in patients with MM undergoing ASCT.

Original language	English
Pages (from-to)	825-832
Number of pages	8
Journal	Leukemia & Lymphoma
Volume	65
Issue number	6
Early online date	21 Feb 2024
DOIs	https://doi.org/10.1080/10428194.2024.2319226
Publication status	Published - 21 Feb 2024

Keywords

Multiple myeloma
sarcopenia
survival
visceral adipose tissue

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10.1080/10428194.2024.2319226Licence: CC BY

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Barajas Ordonez, F., Wolleschak, D., Zeller, Y., Hinnerichs, M., Rodríguez-Feria, P., Aghayev, A., Mikusko, M., Borggrefe, J., Mougiakakos, D., & Surov, A. (2024). Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation. Leukemia & Lymphoma, 65(6), 825-832. https://doi.org/10.1080/10428194.2024.2319226

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title = "Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation",

abstract = "Studies regarding the influence of body composition parameters as predictors on overall survival (OS) in patients with multiple myeloma (MM) are scarce. OS and progression-free survival (PFS) were retrospectively assessed in 129 patients with MM undergoing autologous stem cell transplantation (ASCT) after a follow-up of 2?years. A computed tomography (CT) based semi-automated assessment of body composition was performed. No statistically significant differences were noted in 2-year OS, PFS, or post-transplant adverse events in the body composition groups of subcutaneous adipose tissue (SAT) (low vs. high-SAT), visceral adipose tissue (VAT) (low vs. high-VAT), visceral-to-subcutaneous fat ratio (VSR) (low vs. high VSR), and sarcopenia in terms of skeletal muscle index (SMI) (non-sarcopenic vs. sarcopenic). In conclusion, adipose and muscle tissue do not limit OS or affect the PFS in patients with MM undergoing ASCT.",

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Barajas Ordonez, F, Wolleschak, D, Zeller, Y, Hinnerichs, M, Rodríguez-Feria, P, Aghayev, A, Mikusko, M, Borggrefe, J, Mougiakakos, D & Surov, A 2024, 'Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation', Leukemia & Lymphoma, vol. 65, no. 6, pp. 825-832. https://doi.org/10.1080/10428194.2024.2319226

TY - JOUR

T1 - Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

AU - Barajas Ordonez, Felix

AU - Wolleschak, Denise

AU - Zeller, Yannic

AU - Hinnerichs, Mattes

AU - Rodríguez-Feria, Pablo

AU - Aghayev, Anar

AU - Mikusko, Martin

AU - Borggrefe, Jan

AU - Mougiakakos, Dimitrios

AU - Surov, Alexey

PY - 2024/2/21

Y1 - 2024/2/21

N2 - Studies regarding the influence of body composition parameters as predictors on overall survival (OS) in patients with multiple myeloma (MM) are scarce. OS and progression-free survival (PFS) were retrospectively assessed in 129 patients with MM undergoing autologous stem cell transplantation (ASCT) after a follow-up of 2?years. A computed tomography (CT) based semi-automated assessment of body composition was performed. No statistically significant differences were noted in 2-year OS, PFS, or post-transplant adverse events in the body composition groups of subcutaneous adipose tissue (SAT) (low vs. high-SAT), visceral adipose tissue (VAT) (low vs. high-VAT), visceral-to-subcutaneous fat ratio (VSR) (low vs. high VSR), and sarcopenia in terms of skeletal muscle index (SMI) (non-sarcopenic vs. sarcopenic). In conclusion, adipose and muscle tissue do not limit OS or affect the PFS in patients with MM undergoing ASCT.

AB - Studies regarding the influence of body composition parameters as predictors on overall survival (OS) in patients with multiple myeloma (MM) are scarce. OS and progression-free survival (PFS) were retrospectively assessed in 129 patients with MM undergoing autologous stem cell transplantation (ASCT) after a follow-up of 2?years. A computed tomography (CT) based semi-automated assessment of body composition was performed. No statistically significant differences were noted in 2-year OS, PFS, or post-transplant adverse events in the body composition groups of subcutaneous adipose tissue (SAT) (low vs. high-SAT), visceral adipose tissue (VAT) (low vs. high-VAT), visceral-to-subcutaneous fat ratio (VSR) (low vs. high VSR), and sarcopenia in terms of skeletal muscle index (SMI) (non-sarcopenic vs. sarcopenic). In conclusion, adipose and muscle tissue do not limit OS or affect the PFS in patients with MM undergoing ASCT.

KW - Multiple myeloma

KW - sarcopenia

KW - survival

KW - visceral adipose tissue

U2 - 10.1080/10428194.2024.2319226

DO - 10.1080/10428194.2024.2319226

M3 - Article

SN - 1029-2403

VL - 65

SP - 825

EP - 832

JO - Leukemia & Lymphoma

JF - Leukemia & Lymphoma

IS - 6

ER -

Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

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