Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number52
Number of pages13
JournalClinical epigenetics
Volume11
DOIs
Publication statusPublished - 21 Mar 2019

Keywords

  • Alzheimer's disease (AD)
  • Brain
  • Ankyrin 1 (ANK1)
  • DNA methylation (5mC)
  • DNA hydroxymethylation (5hmC)
  • Entorhinal cortex (EC)
  • Epigenetics
  • Epigenome-wide association study (EWAS)
  • Illumina Infinium Human Methylation 450K microarray (450K array)
  • COMMON VARIANTS
  • 5-HYDROXYMETHYLCYTOSINE
  • PATHWAY
  • ANK1
  • SOFTWARE
  • CD2AP
  • EPHA1
  • CD33

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