Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number52
Number of pages13
JournalClinical epigenetics
Volume11
DOIs
Publication statusPublished - 21 Mar 2019

Keywords

  • Alzheimer's disease (AD)
  • Brain
  • Ankyrin 1 (ANK1)
  • DNA methylation (5mC)
  • DNA hydroxymethylation (5hmC)
  • Entorhinal cortex (EC)
  • Epigenetics
  • Epigenome-wide association study (EWAS)
  • Illumina Infinium Human Methylation 450K microarray (450K array)
  • COMMON VARIANTS
  • 5-HYDROXYMETHYLCYTOSINE
  • PATHWAY
  • ANK1
  • SOFTWARE
  • CD2AP
  • EPHA1
  • CD33

Cite this

Smith, Adam R. ; Smith, Rebecca G. ; Pishva, Ehsan ; Hannon, Eilis ; Roubroeks, Janou A. Y. ; Burrage, Joe ; Troakes, Claire ; Al-Sarraj, Safa ; Sloan, Carolyn ; Mill, Jonathan ; van den Hove, Daniel L. ; Lunnon, Katie. / Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. In: Clinical epigenetics. 2019 ; Vol. 11.
@article{c2ef27c0fa184b5fb77a6a127ebed6a1,
title = "Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease",
keywords = "Alzheimer's disease (AD), Brain, Ankyrin 1 (ANK1), DNA methylation (5mC), DNA hydroxymethylation (5hmC), Entorhinal cortex (EC), Epigenetics, Epigenome-wide association study (EWAS), Illumina Infinium Human Methylation 450K microarray (450K array), COMMON VARIANTS, 5-HYDROXYMETHYLCYTOSINE, PATHWAY, ANK1, SOFTWARE, CD2AP, EPHA1, CD33",
author = "Smith, {Adam R.} and Smith, {Rebecca G.} and Ehsan Pishva and Eilis Hannon and Roubroeks, {Janou A. Y.} and Joe Burrage and Claire Troakes and Safa Al-Sarraj and Carolyn Sloan and Jonathan Mill and {van den Hove}, {Daniel L.} and Katie Lunnon",
year = "2019",
month = "3",
day = "21",
doi = "10.1186/s13148-019-0636-y",
language = "English",
volume = "11",
journal = "Clinical epigenetics",
issn = "1868-7083",
publisher = "BioMed Central Ltd",

}

Smith, AR, Smith, RG, Pishva, E, Hannon, E, Roubroeks, JAY, Burrage, J, Troakes, C, Al-Sarraj, S, Sloan, C, Mill, J, van den Hove, DL & Lunnon, K 2019, 'Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease', Clinical epigenetics, vol. 11, 52. https://doi.org/10.1186/s13148-019-0636-y

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. / Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Hannon, Eilis; Roubroeks, Janou A. Y.; Burrage, Joe; Troakes, Claire; Al-Sarraj, Safa; Sloan, Carolyn; Mill, Jonathan; van den Hove, Daniel L.; Lunnon, Katie.

In: Clinical epigenetics, Vol. 11, 52, 21.03.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

AU - Smith, Adam R.

AU - Smith, Rebecca G.

AU - Pishva, Ehsan

AU - Hannon, Eilis

AU - Roubroeks, Janou A. Y.

AU - Burrage, Joe

AU - Troakes, Claire

AU - Al-Sarraj, Safa

AU - Sloan, Carolyn

AU - Mill, Jonathan

AU - van den Hove, Daniel L.

AU - Lunnon, Katie

PY - 2019/3/21

Y1 - 2019/3/21

KW - Alzheimer's disease (AD)

KW - Brain

KW - Ankyrin 1 (ANK1)

KW - DNA methylation (5mC)

KW - DNA hydroxymethylation (5hmC)

KW - Entorhinal cortex (EC)

KW - Epigenetics

KW - Epigenome-wide association study (EWAS)

KW - Illumina Infinium Human Methylation 450K microarray (450K array)

KW - COMMON VARIANTS

KW - 5-HYDROXYMETHYLCYTOSINE

KW - PATHWAY

KW - ANK1

KW - SOFTWARE

KW - CD2AP

KW - EPHA1

KW - CD33

U2 - 10.1186/s13148-019-0636-y

DO - 10.1186/s13148-019-0636-y

M3 - Article

VL - 11

JO - Clinical epigenetics

JF - Clinical epigenetics

SN - 1868-7083

M1 - 52

ER -