Pain Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with 223Ra: PARABO, a Prospective, Noninterventional Study

Holger Palmedo*, Hojjat Ahmadzadehfar, Susanne Eschmann, Andreas Niesen, Johann Schönberger, Vahé Barsegian, Knut Liepe, Felix M Mottaghy, Rongjin Guan, Joerg Pinkert, Per Sandström, Ken Herrmann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Ra, a targeted a-therapy, is approved for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) who have bone metastases. In the phase 3 ALSYMPCA study, Ra prolonged survival and improved quality of life versus placebo. Our real-world study, PARABO, investigated pain and bone pain-related quality of life in patients with mCRPC and symptomatic bone metastases receiving Ra in clinical practice. PARABO was a prospective, observational, noninterventional single-arm study conducted in nuclear medicine centers across Germany (NCT02398526). The primary endpoint was a clinically meaningful pain response (=2-point improvement from baseline for the worst-pain item score in the Brief Pain Inventory-Short Form). The analysis included 354 patients, who received a median of 6 Ra injections (range, 1-6). Sixty-seven percent (236/354) received 5-6 injections, and 33% (118/354) received 1-4 injections. Of 216 patients with a baseline worst-pain score of more than 1, 59% (128) had a clinically meaningful pain response during treatment. Corresponding rates were 67% (range, 98/146) with 5-6 Ra injections versus 43% (range, 30/70) with 1-4 injections, 60% (range, 60/100) in patients with no more than 20 lesions versus 59% (range, 65/111) in those with more than 20 lesions, and 65% (range, 69/106) in patients without prior or concomitant opioid use versus 54% (range, 59/110) in those with prior or concomitant opioid use. Mean subscale scores (pain severity and pain interference) on the Brief Pain Inventory-Short Form improved during treatment. Ra reduced pain in patients with mCRPC and symptomatic bone metastases, particularly in patients who received 5-6 injections. The extent of metastatic disease did not impact pain response.
Original languageEnglish
Pages (from-to)1392-1398
Number of pages7
JournalJournal of Nuclear Medicine
Volume64
Issue number9
DOIs
Publication statusPublished - 1 Sept 2023

Keywords

  • 223Ra
  • bone metastases
  • castration-resistant prostate cancer
  • pain response
  • targeted a-therapy

Fingerprint

Dive into the research topics of 'Pain Outcomes in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with 223Ra: PARABO, a Prospective, Noninterventional Study'. Together they form a unique fingerprint.

Cite this