Oxidative Stress and Pathological Changes After Coronary Artery Interventions

Rio P. Juni, Henricus J. Duckers, Paul M. Vanhoutte, Renu Virmani, An L. Moens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

80 Citations (Web of Science)

Abstract

Oxidative stress greatly influences the pathogenesis of various cardiovascular disorders. Coronary interventions, including balloon angioplasty and coronary stent implantation, are associated with increased vascular levels of reactive oxygen species in conjunction with altered endothelial cell and smooth muscle cell function. These alterations potentially lead to restenosis, thrombosis, or endothelial dysfunction in the treated artery. Therefore, the understanding of the pathophysiological role of reactive oxygen species (ROS) generated during or after coronary interventions, or both, is essential to improve the success rate of these procedures. Superoxide O-2(center dot-) anions, whether derived from uncoupled endothelial nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, xanthine oxidase, or mitochondria, are among the most harmful ROS. O-2(center dot-) can scavenge nitric oxide, modify proteins and nucleotides, and induce proinflammatory signaling, which may lead to greater ROS production. Current innovations in stent technologies, including biodegradable stents, nitric oxide donor-coated stents, and a new generation of drug-eluting stents, therefore address persistent oxidative stress and reduced nitric oxide bioavailability after percutaneous coronary interventions. This review discusses the molecular mechanisms of ROS generation after coronary interventions, the related pathological events-including restenosis, endothelial dysfunction, and stent thrombosis-and possible therapeutic ways forward. (J Am Coll Cardiol 2013;61:1471-81)
Original languageEnglish
Pages (from-to)1471-1481
JournalJournal of the American College of Cardiology
Volume61
Issue number14
DOIs
Publication statusPublished - 9 Apr 2013

Keywords

  • bare-metal stent(s)
  • drug-eluting stent(s)
  • endothelial dysfunction
  • nitric oxide synthase
  • percutaneous coronary intervention
  • reactive oxygen species
  • superoxide

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