Overview of non-epithelial ovarian tumours: Incidence and survival in the Netherlands, 1989-2015

O. L. Van der Hel*, M. Timmermans, A. M. van Altena, R. F. P. M. Kruitwagen, B. F. M. Slangen, G. S. Sonke, K. K. van de Vijver, M. A. Van der Aa

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)

Abstract

Introduction: About 5% of ovarian tumours have a non-epithelial histology, including germ cell tumours (GCTs), sex cord-stromal tumours (SCSTs) and sarcomas. Because these non-epithelial ovarian tumours are rare and population-based studies are scarce, the aim of this population-based study is to describe trends in the incidence, treatment and survival of women with these tumours in the Netherlands.

Methods: All women diagnosed with non-epithelial ovarian malignant tumours in the Netherlands between 1989 and 2015 were identified from the Netherlands Cancer Registry. Data on demographics, tumour characteristics and initial treatment were collected, and overall survival was analysed.

Results: A total of 1258 non-epithelial ovarian tumours were identified comprising 752 GCTs (60%), 341 SCSTs (27%) and 165 sarcomas (13%). The European age-standardised incidence rate (ESR) was 0.4 per 100,000 persons per year for GCTs, 0.2 for SCSTs and 0.1 for sarcomas. Approximately 97% of patients underwent surgical resection for the primary tumour, 31% received systemic treatment and 3% radiotherapy. Between the late 1980s and 2015, five-year overall survival improved for all histologic subtypes: GCTs rose from 73% to 88% (p = 0.03), SCSTs from 64% to 81% (p = 0.57) and sarcomas from 20% to 29% (p = 0.14).

Conclusion: Malignant GCTs and SCSTs are rare, and their incidence has not significantly changed over recent decades. They have a good prognosis, which also improved slightly during this period. Primary sarcomas of the ovary are extremely rare and still have a poor prognosis. (C) 2019 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalEuropean Journal of Cancer
Volume118
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Ovarian neoplasms
  • Incidence
  • Histology
  • Rare cancer
  • Ovarian germ cell tumours
  • Sex cord-stromal tumours
  • Ovarian sarcoma
  • Overall survival
  • CANCER INCIDENCE
  • STAGE-I
  • CELL TUMORS
  • SURGERY
  • MANAGEMENT
  • PATHOLOGY
  • OUTCOMES

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