Overall survival in patients with a re-excision following breast conserving surgery compared to those without in a large population-based cohort

E.L. Vos, A. Jager, C. Verhoef, A.C. Voogd, L.B. Koppert

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Aim: To investigate the overall survival of invasive breast cancer patients with primary breast conserving surgery (BCS) followed by re-excision compared to those with primary BCS only. The Dutch re-excision indications are less stringent compared to other European and Northern American countries (Society of Surgical Oncology-American Society for Radiation Oncology (SSO/ASTRO) guideline).

Methods: Retrospective analyses in women

Results: A total of 11,695 patients were included of which 2156 (18.4%) underwent re-excision. Median time of follow-up was 61 months (interquartile range (IQR) 26-101). The 5-year overall survival rates in the 'primary BCS only', 're-excision by BCS' and 're-excision by mastectomy' group were 92%, 95% and 91%, respectively. The 10-year overall survival rates were 81%, 82% and 79%, respectively (P = 0.20). After multivariable analyses no significant association was observed between use of and type of re-excision and overall survival.

Conclusions: The overall survival of breast cancer patients with a re-excision did not significantly differ from the survival of women who underwent primary BCS only. Advising re-excision only for those tumours showing 'more than focally positive' resection margin appears safe, supposing the long-term safety of the recent SSO/ASTRO guideline that more cautiously recommended re-excision for tumours showing 'ink on tumour'. (C) 2014 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)282-291
Number of pages10
JournalEuropean Journal of Cancer
Volume51
Issue number3
DOIs
Publication statusPublished - Feb 2015

Keywords

  • Breast cancer
  • Breast conserving surgery
  • Re-excision
  • Overall survival
  • ONCOLOGY CONSENSUS GUIDELINE
  • LOCAL RECURRENCE
  • SURGICAL MARGINS
  • CONSERVATION TREATMENT
  • ADJUVANT CHEMOTHERAPY
  • LUMPECTOMY MARGINS
  • RANDOMIZED-TRIALS
  • AMERICAN SOCIETY
  • CANCER PATIENTS
  • STAGES I

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