Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

T.S. Ellison, S.F. Cappa, D. Garrett, J. Georges, T. Iwatsubo, J.H. Kramer, M. Lehmann, C. Lyketsos, A.B. Maier, J. Merrilees, J.C. Morris, S.L. Naismith, F. Nobili, M. Pahor, D. Pond, L. Robinson, P. Soysal, M. Vandenbulcke, C.J. Weber, P.J. VisserM. Weiner, G.B. Frisoni*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.
Original languageEnglish
Pages (from-to)2707-2729
Number of pages23
JournalAlzheimer's & Dementia
Volume19
Issue number6
Early online date1 Feb 2023
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Alzheimer's disease
  • consensus
  • Delphi
  • dementia
  • measures
  • outcomes
  • MILD COGNITIVE IMPAIRMENT
  • QUALITY-OF-LIFE
  • FUNCTIONAL-ACTIVITIES QUESTIONNAIRE
  • DAILY LIVING SCALE
  • REVISED ACE-R
  • INSTRUMENTAL-ACTIVITIES
  • NEUROPSYCHIATRIC INVENTORY
  • DEPRESSION SCALE
  • OLDER-ADULTS
  • CORNELL SCALE

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