Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

T.S. Ellison; S.F. Cappa; D. Garrett; J. Georges; T. Iwatsubo; J.H. Kramer; M. Lehmann; C. Lyketsos; A.B. Maier; J. Merrilees; J.C. Morris; S.L. Naismith; F. Nobili; M. Pahor; D. Pond; L. Robinson; P. Soysal; M. Vandenbulcke; C.J. Weber; P.J. Visser; M. Weiner; G.B. Frisoni

doi:10.1002/alz.12945

Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

T.S. Ellison, S.F. Cappa, D. Garrett, J. Georges, T. Iwatsubo, J.H. Kramer, M. Lehmann, C. Lyketsos, A.B. Maier, J. Merrilees, J.C. Morris, S.L. Naismith, F. Nobili, M. Pahor, D. Pond, L. Robinson, P. Soysal, M. Vandenbulcke, C.J. Weber, P.J. VisserM. Weiner, G.B. Frisoni^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

Original language	English
Pages (from-to)	2707-2729
Number of pages	23
Journal	Alzheimer's & Dementia
Volume	19
Issue number	6
Early online date	1 Feb 2023
DOIs	https://doi.org/10.1002/alz.12945
Publication status	Published - Jun 2023

Keywords

Alzheimer's disease
consensus
Delphi
dementia
measures
outcomes
MILD COGNITIVE IMPAIRMENT
QUALITY-OF-LIFE
FUNCTIONAL-ACTIVITIES QUESTIONNAIRE
DAILY LIVING SCALE
REVISED ACE-R
INSTRUMENTAL-ACTIVITIES
NEUROPSYCHIATRIC INVENTORY
DEPRESSION SCALE
OLDER-ADULTS
CORNELL SCALE

Access to Document

10.1002/alz.12945Licence: CC BY-NC

Cite this

Ellison, T. S., Cappa, S. F., Garrett, D., Georges, J., Iwatsubo, T., Kramer, J. H., Lehmann, M., Lyketsos, C., Maier, A. B., Merrilees, J., Morris, J. C., Naismith, S. L., Nobili, F., Pahor, M., Pond, D., Robinson, L., Soysal, P., Vandenbulcke, M., Weber, C. J., ... Frisoni, G. B. (2023). Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus. Alzheimer's & Dementia, 19(6), 2707-2729. https://doi.org/10.1002/alz.12945

@article{2e8795050e784a268ca899062a06f1dd,

title = "Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus",

abstract = "IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.",

keywords = "Alzheimer's disease, consensus, Delphi, dementia, measures, outcomes, MILD COGNITIVE IMPAIRMENT, QUALITY-OF-LIFE, FUNCTIONAL-ACTIVITIES QUESTIONNAIRE, DAILY LIVING SCALE, REVISED ACE-R, INSTRUMENTAL-ACTIVITIES, NEUROPSYCHIATRIC INVENTORY, DEPRESSION SCALE, OLDER-ADULTS, CORNELL SCALE",

author = "T.S. Ellison and S.F. Cappa and D. Garrett and J. Georges and T. Iwatsubo and J.H. Kramer and M. Lehmann and C. Lyketsos and A.B. Maier and J. Merrilees and J.C. Morris and S.L. Naismith and F. Nobili and M. Pahor and D. Pond and L. Robinson and P. Soysal and M. Vandenbulcke and C.J. Weber and P.J. Visser and M. Weiner and G.B. Frisoni",

year = "2023",

month = jun,

doi = "10.1002/alz.12945",

language = "English",

volume = "19",

pages = "2707--2729",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier Science",

number = "6",

}

Ellison, TS, Cappa, SF, Garrett, D, Georges, J, Iwatsubo, T, Kramer, JH, Lehmann, M, Lyketsos, C, Maier, AB, Merrilees, J, Morris, JC, Naismith, SL, Nobili, F, Pahor, M, Pond, D, Robinson, L, Soysal, P, Vandenbulcke, M, Weber, CJ, Visser, PJ, Weiner, M & Frisoni, GB 2023, 'Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus', Alzheimer's & Dementia, vol. 19, no. 6, pp. 2707-2729. https://doi.org/10.1002/alz.12945

TY - JOUR

T1 - Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

AU - Ellison, T.S.

AU - Cappa, S.F.

AU - Garrett, D.

AU - Georges, J.

AU - Iwatsubo, T.

AU - Kramer, J.H.

AU - Lehmann, M.

AU - Lyketsos, C.

AU - Maier, A.B.

AU - Merrilees, J.

AU - Morris, J.C.

AU - Naismith, S.L.

AU - Nobili, F.

AU - Pahor, M.

AU - Pond, D.

AU - Robinson, L.

AU - Soysal, P.

AU - Vandenbulcke, M.

AU - Weber, C.J.

AU - Visser, P.J.

AU - Weiner, M.

AU - Frisoni, G.B.

PY - 2023/6

Y1 - 2023/6

N2 - IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

AB - IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

KW - Alzheimer's disease

KW - consensus

KW - Delphi

KW - dementia

KW - measures

KW - outcomes

KW - MILD COGNITIVE IMPAIRMENT

KW - QUALITY-OF-LIFE

KW - FUNCTIONAL-ACTIVITIES QUESTIONNAIRE

KW - DAILY LIVING SCALE

KW - REVISED ACE-R

KW - INSTRUMENTAL-ACTIVITIES

KW - NEUROPSYCHIATRIC INVENTORY

KW - DEPRESSION SCALE

KW - OLDER-ADULTS

KW - CORNELL SCALE

U2 - 10.1002/alz.12945

DO - 10.1002/alz.12945

M3 - Article

C2 - 36749854

SN - 1552-5260

VL - 19

SP - 2707

EP - 2729

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 6

ER -