Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region

N. Thielen, M. Neefjes, R. Wiegertjes, G. van den Akker, E. Vitters, H. van Beuningen, E.B. Davidson, M. Koenders, P. van Lent, F. van de Loo, A. van Caam, P. van der Kraan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number8124
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume22
Issue number15
DOIs
Publication statusPublished - 1 Aug 2021

Keywords

  • TGF-beta
  • osteoarthritis
  • cartilage
  • SMAD2
  • 3 signaling
  • linker modifications
  • inflammation
  • TERMINAL DOMAIN PHOSPHATASES
  • ARTICULAR CHONDROCYTES
  • TUMOR-SUPPRESSION
  • GENE-EXPRESSION
  • DOWN-REGULATION
  • UP-REGULATION
  • PHOSPHORYLATION
  • CARTILAGE
  • CYTOKINES
  • INTERLEUKIN-1-BETA

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