Optimizing Bone Scaffold Porosity Distributions

Patrina S. P. Poh; Dvina Valainis; Kaushik Bhattacharya; Martijn van Griensven; Patrick Dondl

Optimizing Bone Scaffold Porosity Distributions

Patrina S. P. Poh, Dvina Valainis, Kaushik Bhattacharya, Martijn van Griensven, Patrick Dondl^*

^*Corresponding author for this work

Research output: Working paper / Preprint › Preprint

Abstract

We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.

Original language	English
Publisher	Cornell University - arXiv
Publication status	Published - 21 Sept 2018
Externally published	Yes

Publication series

Series	arXiv.org
ISSN	2331-8422

Keywords

q-bio.TO
35Q92, 35Q93, 74L15, 97M60

Access to Document

https://arxiv.org/abs/1809.08179Licence: Unspecified

Cite this

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title = "Optimizing Bone Scaffold Porosity Distributions",

abstract = " We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced. ",

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AU - Valainis, Dvina

AU - Bhattacharya, Kaushik

AU - van Griensven, Martijn

AU - Dondl, Patrick

PY - 2018/9/21

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N2 - We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.

AB - We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.

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BT - Optimizing Bone Scaffold Porosity Distributions

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