Optimizing Bone Scaffold Porosity Distributions

Patrina S. P. Poh, Dvina Valainis, Kaushik Bhattacharya, Martijn van Griensven, Patrick Dondl*

*Corresponding author for this work

Research output: Working paper / PreprintPreprint

Abstract

We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.
Original languageEnglish
PublisherCornell University - arXiv
DOIs
Publication statusPublished - 21 Sept 2018
Externally publishedYes

Publication series

SeriesarXiv.org
ISSN2331-8422

Keywords

  • q-bio.TO
  • 35Q92, 35Q93, 74L15, 97M60

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