Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future

Orit Kaidar-Person; Trine Tramm; Thorsten Kuehn; Oreste Gentilini; Aleix Prat; Pierre Montay-Gruel; Icro Meattini; Philip Poortmans

doi:10.1007/s11547-023-01743-1

Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future

Orit Kaidar-Person^*, Trine Tramm, Thorsten Kuehn, Oreste Gentilini, Aleix Prat, Pierre Montay-Gruel, Icro Meattini, Philip Poortmans

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing the magnitude of axillary therapy (surgery versus radiation) on cancer control. Considering that both systemic and loco-regional therapies were shown to reduce any recurrence with a complex interaction, our review includes surgical, radiation, and radiobiology consideration for breast cancer, and provide our view of future practise. The aim is to provide information optimise radiation therapy in the era of primary systemic therapy.

Original language	English
Pages (from-to)	315-327
Number of pages	13
Journal	Radiologia medica
Volume	129
Issue number	2
Early online date	3 Nov 2023
DOIs	https://doi.org/10.1007/s11547-023-01743-1
Publication status	Published - Feb 2024

Keywords

Axilla
Axillary dissection
Breast cancer
Lymph nodes
Radiation therapy
Radiotherapy
Surgery

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10.1007/s11547-023-01743-1

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title = "Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future",

abstract = "In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing the magnitude of axillary therapy (surgery versus radiation) on cancer control. Considering that both systemic and loco-regional therapies were shown to reduce any recurrence with a complex interaction, our review includes surgical, radiation, and radiobiology consideration for breast cancer, and provide our view of future practise. The aim is to provide information optimise radiation therapy in the era of primary systemic therapy.",

keywords = "Axilla, Axillary dissection, Breast cancer, Lymph nodes, Radiation therapy, Radiotherapy, Surgery",

author = "Orit Kaidar-Person and Trine Tramm and Thorsten Kuehn and Oreste Gentilini and Aleix Prat and Pierre Montay-Gruel and Icro Meattini and Philip Poortmans",

note = "Publisher Copyright: {\textcopyright} 2023, Italian Society of Medical Radiology.",

year = "2024",

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doi = "10.1007/s11547-023-01743-1",

language = "English",

volume = "129",

pages = "315--327",

journal = "Radiologia medica",

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publisher = "Springer Verlag",

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TY - JOUR

T1 - Optimising of axillary therapy in breast cancer

T2 - lessons from the past to plan for a better future

AU - Kaidar-Person, Orit

AU - Tramm, Trine

AU - Kuehn, Thorsten

AU - Gentilini, Oreste

AU - Prat, Aleix

AU - Montay-Gruel, Pierre

AU - Meattini, Icro

AU - Poortmans, Philip

PY - 2024/2

Y1 - 2024/2

N2 - In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing the magnitude of axillary therapy (surgery versus radiation) on cancer control. Considering that both systemic and loco-regional therapies were shown to reduce any recurrence with a complex interaction, our review includes surgical, radiation, and radiobiology consideration for breast cancer, and provide our view of future practise. The aim is to provide information optimise radiation therapy in the era of primary systemic therapy.

AB - In this narrative review, we aim to explore the ability of radiation therapy to eradicate breast cancer regional node metastasis. It is a journey through data of older trials without systemic therapy showing the magnitude of axillary therapy (surgery versus radiation) on cancer control. Considering that both systemic and loco-regional therapies were shown to reduce any recurrence with a complex interaction, our review includes surgical, radiation, and radiobiology consideration for breast cancer, and provide our view of future practise. The aim is to provide information optimise radiation therapy in the era of primary systemic therapy.

KW - Axilla

KW - Axillary dissection

KW - Breast cancer

KW - Lymph nodes

KW - Radiation therapy

KW - Radiotherapy

KW - Surgery

U2 - 10.1007/s11547-023-01743-1

DO - 10.1007/s11547-023-01743-1

M3 - (Systematic) Review article

SN - 0033-8362

VL - 129

SP - 315

EP - 327

JO - Radiologia medica

JF - Radiologia medica

IS - 2

ER -

Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future

Abstract

Keywords

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