TY - JOUR
T1 - One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients
T2 - results from the ColoCare Study
AU - Kiblawi, Rama
AU - Holowatyj, Andreana N.
AU - Gigic, Biljana
AU - Brezina, Stefanie
AU - Geijsen, Anne J. M. R.
AU - Ose, Jennifer
AU - Lin, Tengda
AU - Hardikar, Sheetal
AU - Himbert, Caroline
AU - Warby, Christy A.
AU - Boehm, Juergen
AU - Bourse, Martijn J. L.
AU - van Duijnhoven, Fraenzel J. B.
AU - Gumpenberger, Tanja
AU - Kok, Dieuwertje E.
AU - Koole, Janna L.
AU - van Roekel, Eline H.
AU - Schrotz-King, Petra
AU - Ulvikl, Arve
AU - Gsur, Andrea
AU - Habermann, Nina
AU - Weijenberg, Matty P.
AU - Ueland, Per Magne
AU - Schneiders, Martin
AU - Ulrich, Alexis
AU - Ulrich, Cornelia M.
AU - Playdon, Mary
PY - 2020/5/28
Y1 - 2020/5/28
N2 - B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5'-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r -0 center dot 33, P-linear <0 center dot 0001), serum amyloid A (SAA) (r -0 center dot 23, P-linear = 0 center dot 003), IL-6 (r -0 center dot 39, P-linear <0 center dot 0001), IL-8 (r -0 center dot 20, P-linear = 0 center dot 02) and TNF alpha (r -0 center dot 12, P-linear = 0 center dot 045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r -0 center dot 14), SAA (r -0 center dot 14) and TNF alpha (r -0 center dot 15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0 center dot 27, P-linear <0 center dot 0001), and pABG was positively correlated with IL-8 (r 0 center dot 21, P-linear <0 center dot 0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.
AB - B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5'-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r -0 center dot 33, P-linear <0 center dot 0001), serum amyloid A (SAA) (r -0 center dot 23, P-linear = 0 center dot 003), IL-6 (r -0 center dot 39, P-linear <0 center dot 0001), IL-8 (r -0 center dot 20, P-linear = 0 center dot 02) and TNF alpha (r -0 center dot 12, P-linear = 0 center dot 045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r -0 center dot 14), SAA (r -0 center dot 14) and TNF alpha (r -0 center dot 15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0 center dot 27, P-linear <0 center dot 0001), and pABG was positively correlated with IL-8 (r 0 center dot 21, P-linear <0 center dot 0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of PLP and other one-carbon metabolites with inflammatory processes among colorectal carcinogenesis and prognosis could identify targets for future dietary guidance for CRC patients.
KW - One-carbon metabolism
KW - B vitamins
KW - Folate
KW - Vitamin B-6
KW - Inflammation
KW - Colorectal cancer
KW - Angiogenesis
KW - C-REACTIVE PROTEIN
KW - FOLIC-ACID SUPPLEMENTATION
KW - PYRIDOXAL 5'-PHOSPHATE
KW - PLASMA HOMOCYSTEINE
KW - THIAMINE-DEFICIENCY
KW - OXIDATIVE STRESS
KW - RISK
KW - FOLATE
KW - CATABOLISM
KW - ASPIRIN
U2 - 10.1017/S0007114520000422
DO - 10.1017/S0007114520000422
M3 - Article
C2 - 32019627
VL - 123
SP - 1187
EP - 1200
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
M1 - 0007114520000422
ER -