Obstructive sleep apnea and the risk of gout: a population-based case-control study

Caroline van Durme; Bart Spaetgens; Johanna Driessen; Johannes Nielen; Manuel Sastry; Annelies Boonen; Frank de Vries

doi:10.1186/s13075-020-02176-1

Obstructive sleep apnea and the risk of gout: a population-based case-control study

Caroline van Durme, Bart Spaetgens, Johanna Driessen, Johannes Nielen, Manuel Sastry, Annelies Boonen, Frank de Vries^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA.

METHODS: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use.

RESULTS: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population.

CONCLUSION: This study showed that the observed association between OSA and gout disappeared after adjustment.

Original language	English
Article number	92
Number of pages	9
Journal	Arthritis Research & Therapy
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s13075-020-02176-1
Publication status	Published - 25 Apr 2020

Keywords

Gout
Obstructive sleep apnea (OSA)
Case-control study
Comorbidity
HEART-FAILURE
URIC-ACID
HIGH PREVALENCE
HYPERURICEMIA
COMORBIDITIES

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Cite this

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title = "Obstructive sleep apnea and the risk of gout: a population-based case-control study",

abstract = "BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA.METHODS: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use.RESULTS: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population.CONCLUSION: This study showed that the observed association between OSA and gout disappeared after adjustment.",

keywords = "Gout, Obstructive sleep apnea (OSA), Case-control study, Comorbidity, HEART-FAILURE, URIC-ACID, HIGH PREVALENCE, HYPERURICEMIA, COMORBIDITIES",

author = "{van Durme}, Caroline and Bart Spaetgens and Johanna Driessen and Johannes Nielen and Manuel Sastry and Annelies Boonen and {de Vries}, Frank",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

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language = "English",

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T1 - Obstructive sleep apnea and the risk of gout

T2 - a population-based case-control study

AU - van Durme, Caroline

AU - Spaetgens, Bart

AU - Driessen, Johanna

AU - Nielen, Johannes

AU - Sastry, Manuel

AU - Boonen, Annelies

AU - de Vries, Frank

PY - 2020/4/25

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N2 - BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA.METHODS: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use.RESULTS: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population.CONCLUSION: This study showed that the observed association between OSA and gout disappeared after adjustment.

AB - BACKGROUND: Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both diseases. The objective of the present study was to investigate the risk of gout in patients with OSA.METHODS: A population-based case-control study using the UK Clinical Practice Research Datalink GOLD including all patients aged 40 years and older with a first diagnosis of gout between 1987 and 2014. Gout cases were matched by year of birth, sex, and practice to non-gout controls. Conditional logistic regression estimated the risk of gout with an earlier diagnosis of OSA. Analyses were adjusted for lifestyle factors, comorbidities, and recent drug use.RESULTS: One hundred eleven thousand five hundred nine cases were matched with 210,241 controls. Patients with OSA were at increased risk of gout (OR 1.86; 95%CI (1.71-2.02). However, this association disappeared (OR 1.05; 95% CI 0.96-1.16) after adjustment for smoking status, body mass index (BMI), alcohol use, a history of heart failure, diabetes mellitus, renal function, and recent use of diuretics and other medications. Among females with OSA and patients with OSA associated with heart failure, renal impairment, or higher BMI, the risk of gout was however still increased when compared to the total control population.CONCLUSION: This study showed that the observed association between OSA and gout disappeared after adjustment.

KW - Gout

KW - Obstructive sleep apnea (OSA)

KW - Case-control study

KW - Comorbidity

KW - HEART-FAILURE

KW - URIC-ACID

KW - HIGH PREVALENCE

KW - HYPERURICEMIA

KW - COMORBIDITIES

U2 - 10.1186/s13075-020-02176-1

DO - 10.1186/s13075-020-02176-1

M3 - Article

C2 - 32334617

SN - 1478-6354

VL - 22

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 1

M1 - 92

ER -