OBJECTIVE: Obesity is a key factor in the development of the metabolic (MetS), which is associated with increased cardiometabolic risk. We whether obesity classification by BMI and body fat percentage (BF%) cardiometabolic profile and dietary responsiveness in 486 MetS subjects dietary intervention study). DESIGN AND METHODS: Anthropometric of inflammation and glucose metabolism, lipid profiles, adhesion hemostatic factors were determined at baseline and after 12 weeks of interventions (high saturated fat (SFA), high monounsaturated fat low fat high complex carbohydrate (LFHCC) diets, one supplemented with n-3 polyunsaturated fatty acids (LC n-3 PUFAs)). RESULTS: About 39 and subjects classified as normal and overweight by BMI were obese according BF%. Individuals classified as obese by BMI (>/=30 kg/m(2) ) and BF% (men) and >/=35% (women)) (OO, n = 284) had larger waist and hip higher BMI and were heavier (P < 0.001) than those classified as but obese by BF% (NOO, n = 92). OO individuals displayed a more (higher C reactive protein (CRP) and leptin), prothrombotic (higher activator inhibitor-1 (PAI-1)), proatherogenic (higher and more insulin resistant (higher HOMA-IR) metabolic profile relative group (P < 0.001). Interestingly, tumor necrosis factor-alpha (TNF- concentrations were lower post-intervention in NOO individuals compared subjects (P < 0.001). CONCLUSIONS: In conclusion, assessing BF% and BMI of a metabotype may help to identify individuals at greater than BMI alone.