TY - JOUR
T1 - Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
AU - Heath, A.K.
AU - Muller, D.C.
AU - van den Brandt, P.A.
AU - Papadimitriou, N.
AU - Critselis, E.
AU - Gunter, M.
AU - Vineis, P.
AU - Weiderpass, E.
AU - Fagherazzi, G.
AU - Boeing, H.
AU - Ferrari, P.
AU - Olsen, A.
AU - Tjonneland, A.
AU - Arveux, P.
AU - Boutron-Ruault, M.C.
AU - Mancini, F.R.
AU - Kuhn, T.
AU - Turzanski-Fortner, R.
AU - Schulze, M.B.
AU - Karakatsani, A.
AU - Thriskos, P.
AU - Trichopoulou, A.
AU - Masala, G.
AU - Contiero, P.
AU - Ricceri, F.
AU - Panico, S.
AU - Bueno-de-Mesquita, B.
AU - Bakker, M.F.
AU - van Gils, C.H.
AU - Olsen, K.S.
AU - Skeie, G.
AU - Lasheras, C.
AU - Agudo, A.
AU - Rodriguez-Barranco, M.
AU - Sanchez, M.J.
AU - Amiano, P.
AU - Chirlaque, M.D.
AU - Barricarte, A.
AU - Drake, I.
AU - Ericson, U.
AU - Johansson, I.
AU - Winkvist, A.
AU - Key, T.
AU - Freisling, H.
AU - His, M.
AU - Huybrechts, I.
AU - Christakoudi, S.
AU - Ellingjord-Dale, M.
AU - Riboli, E.
AU - Tsilidis, K.K.
N1 - Funding Information:
This work was supported by the World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme (WCRF 2014/1180 to Konstantinos K Tsilidis). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS), Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia, Navarra, and the Catalan Institute of Oncology (Barcelona) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/ M012190/1 to EPIC-Oxford) (UK). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/1/13
Y1 - 2020/1/13
N2 - Background Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
AB - Background Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
KW - alcohol
KW - breast cancer
KW - diet
KW - dietary fiber intake
KW - fibre
KW - foods
KW - metaanalysis
KW - nutrients
KW - nutrition
KW - pooled analysis
KW - postmenopausal women
KW - premenopausal
KW - questionnaire
KW - scale prospective cohort
KW - serum estrogen concentrations
KW - SERUM ESTROGEN CONCENTRATIONS
KW - METAANALYSIS
KW - Alcohol
KW - DIETARY FIBER INTAKE
KW - SCALE PROSPECTIVE COHORT
KW - ALCOHOL
KW - Nutrients
KW - Fibre
KW - POOLED ANALYSIS
KW - POSTMENOPAUSAL WOMEN
KW - QUESTIONNAIRE
KW - Breast cancer
KW - Diet
KW - NUTRITION
KW - Foods
KW - PREMENOPAUSAL
UR - https://springernature.figshare.com/articles/dataset/MOESM1_of_Nutrient-wide_association_study_of_92_foods_and_nutrients_and_breast_cancer_risk/11598735/1
UR - https://springernature.figshare.com/articles/dataset/MOESM2_of_Nutrient-wide_association_study_of_92_foods_and_nutrients_and_breast_cancer_risk/11598756/1
U2 - 10.1186/s13058-019-1244-7
DO - 10.1186/s13058-019-1244-7
M3 - Article
C2 - 31931881
SN - 1465-5411
VL - 22
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 5
ER -