Novel genes for familial combined hyperlipidemia.

B.E. Aouizerat, H. Allayee, J. Bodnar, K.L. Krass, L. Peltonen, T.W.A. de Bruin, J.L. Rotter, A.J. Lusis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.

Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

Publication Types:
Review
Review, Tutorial
Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalCurrent Opinion in Lipidology
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Jan 1999

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