Novel genes for familial combined hyperlipidemia.

B.E. Aouizerat; H. Allayee; J. Bodnar; K.L. Krass; L. Peltonen; T.W.A. de Bruin; J.L. Rotter; A.J. Lusis

doi:10.1097/00041433-199904000-00005

Novel genes for familial combined hyperlipidemia.

B.E. Aouizerat, H. Allayee, J. Bodnar, K.L. Krass, L. Peltonen, T.W.A. de Bruin, J.L. Rotter, A.J. Lusis^*

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.

Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

Publication Types:
Review
Review, Tutorial

Original language	English
Pages (from-to)	113-122
Number of pages	10
Journal	Current Opinion in Lipidology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1097/00041433-199904000-00005
Publication status	Published - 1 Jan 1999

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10.1097/00041433-199904000-00005

Cite this

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title = "Novel genes for familial combined hyperlipidemia.",

abstract = "Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.Publication Types: Review Review, Tutorial",

author = "B.E. Aouizerat and H. Allayee and J. Bodnar and K.L. Krass and L. Peltonen and {de Bruin}, T.W.A. and J.L. Rotter and A.J. Lusis",

year = "1999",

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T1 - Novel genes for familial combined hyperlipidemia.

AU - Aouizerat, B.E.

AU - Allayee, H.

AU - Bodnar, J.

AU - Krass, K.L.

AU - Peltonen, L.

AU - de Bruin, T.W.A.

AU - Rotter, J.L.

AU - Lusis, A.J.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.Publication Types: Review Review, Tutorial

AB - Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1679, USA.Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.Publication Types: Review Review, Tutorial

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DO - 10.1097/00041433-199904000-00005

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