Noninvasive Assessment of Arterial Stiffness Should Discriminate Between Systolic and Diastolic Pressure Ranges

Evelien Hermeling, Arnold P. G. Hoeks, Mark H. M. Winkens, Johannes L. Waltenberger, Robert S. Reneman, Abraham A. Kroon, Koen D. Reesink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Arterial stiffening plays an important role in the development of hypertension and cardiovascular diseases. The intrinsically nonlinear (ie, pressure-dependent) elastic behavior of arteries may have serious consequences for the accuracy and interpretation of arterial stiffness measurements and, ultimately, for individual patient management. We determined aortic pressure and common carotid artery diameter waveforms in 21 patients undergoing cardiac catheterization. The individual pressure-area curves were described using a dual exponential analytic model facilitating noise-free calculation of incremental pulse wave velocity. In addition, compliance coefficients were calculated separately in the diastolic and systolic pressure ranges, only using diastolic, dicrotic notch, and systolic data points, which can be determined noninvasively. Pulse wave velocity at systolic pressure exhibited a much stronger positive correlation with pulse pressure (P140 mm Hg) had a 2.5-times lower compliance coefficient in the systolic pressure range than patients with systolic blood pressures
Original languageEnglish
Pages (from-to)124-130
Issue number1
Publication statusPublished - Jan 2010


  • arterial structure and compliance
  • pulse wave velocity
  • blood pressure measurement
  • systolic hypertension
  • carotid arteries

Cite this