Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator

Dirk De Ruysscher; Patrick Vincent Granton; Natasja Gaby Lieuwes; Stefan van Hoof; Lutz Wollin; Birgit Weynand; Anne-Marie Dingemans; Frank Verhaegen; Ludwig Dubois

doi:10.1016/j.radonc.2017.07.014

Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator

Dirk De Ruysscher, Patrick Vincent Granton, Natasja Gaby Lieuwes, Stefan van Hoof, Lutz Wollin, Birgit Weynand, Anne-Marie Dingemans, Frank Verhaegen, Ludwig Dubois^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Web of Science)

122 Downloads (Pure)

Original language	English
Pages (from-to)	482-487
Number of pages	6
Journal	Radiotherapy and Oncology
Volume	124
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2017.07.014
Publication status	Published - Sep 2017
Event	15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology - SWITZERLAND, Switzerland Duration: 17 Jun 2017 → 19 Jun 2017

Keywords

Nintedanib
Radiation-induced lung damage
Radiation pneumonitis
Radiation fibrosis
Small animal image-guided precision irradiation
IDIOPATHIC PULMONARY-FIBROSIS
THORACIC IRRADIATION
RADIOTHERAPY
THERAPIES
DAMAGE
MICE
PNEUMONITIS
PROGRESSION
STRAINS
SEARCH

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10.1016/j.radonc.2017.07.014

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Cite this

De Ruysscher, D., Granton, P. V., Lieuwes, N. G., van Hoof, S., Wollin, L., Weynand, B., Dingemans, A-M., Verhaegen, F., & Dubois, L. (2017). Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator. Radiotherapy and Oncology, 124(3), 482-487. https://doi.org/10.1016/j.radonc.2017.07.014

De Ruysscher, Dirk ; Granton, Patrick Vincent ; Lieuwes, Natasja Gaby ; van Hoof, Stefan ; Wollin, Lutz ; Weynand, Birgit ; Dingemans, Anne-Marie ; Verhaegen, Frank ; Dubois, Ludwig. / Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging : A preclinical study with a high precision image-guided irradiator. In: Radiotherapy and Oncology. 2017 ; Vol. 124, No. 3. pp. 482-487.

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title = "Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator",

keywords = "Nintedanib, Radiation-induced lung damage, Radiation pneumonitis, Radiation fibrosis, Small animal image-guided precision irradiation, IDIOPATHIC PULMONARY-FIBROSIS, THORACIC IRRADIATION, RADIOTHERAPY, THERAPIES, DAMAGE, MICE, PNEUMONITIS, PROGRESSION, STRAINS, SEARCH",

author = "{De Ruysscher}, Dirk and Granton, {Patrick Vincent} and Lieuwes, {Natasja Gaby} and {van Hoof}, Stefan and Lutz Wollin and Birgit Weynand and Anne-Marie Dingemans and Frank Verhaegen and Ludwig Dubois",

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journal = "Radiotherapy and Oncology",

issn = "0167-8140",

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De Ruysscher, D, Granton, PV, Lieuwes, NG, van Hoof, S, Wollin, L, Weynand, B, Dingemans, A-M , Verhaegen, F & Dubois, L 2017, 'Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator', Radiotherapy and Oncology, vol. 124, no. 3, pp. 482-487. https://doi.org/10.1016/j.radonc.2017.07.014

Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging : A preclinical study with a high precision image-guided irradiator. / De Ruysscher, Dirk; Granton, Patrick Vincent; Lieuwes, Natasja Gaby; van Hoof, Stefan; Wollin, Lutz; Weynand, Birgit; Dingemans, Anne-Marie ; Verhaegen, Frank ; Dubois, Ludwig.

In: Radiotherapy and Oncology, Vol. 124, No. 3, 09.2017, p. 482-487.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Nintedanib reduces radiation -induced microscopic lung fibrosis but this cannot be monitored by CT imaging

T2 - 15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology

AU - De Ruysscher, Dirk

AU - Granton, Patrick Vincent

AU - Lieuwes, Natasja Gaby

AU - van Hoof, Stefan

AU - Wollin, Lutz

AU - Weynand, Birgit

AU - Dingemans, Anne-Marie

AU - Verhaegen, Frank

AU - Dubois, Ludwig

PY - 2017/9

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KW - Nintedanib

KW - Radiation-induced lung damage

KW - Radiation pneumonitis

KW - Radiation fibrosis

KW - Small animal image-guided precision irradiation

KW - IDIOPATHIC PULMONARY-FIBROSIS

KW - THORACIC IRRADIATION

KW - RADIOTHERAPY

KW - THERAPIES

KW - DAMAGE

KW - MICE

KW - PNEUMONITIS

KW - PROGRESSION

KW - STRAINS

KW - SEARCH

U2 - 10.1016/j.radonc.2017.07.014

DO - 10.1016/j.radonc.2017.07.014

M3 - Article

C2 - 28774597

VL - 124

SP - 482

EP - 487

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 3

Y2 - 17 June 2017 through 19 June 2017

ER -