Abstract
This thesis describes new insights into deep brain stimulation in otherwise treatment-resistant patients with Tourette Syndrome. Although the exact cause of Tourette Syndrome is largely unknown, it is shown that basal ganglia dysfunction plays a role. Deep brain stimulation activates certain areas within the basal ganglia. We found that thalamus stimulation has marked short-term tic-reducing effects. In the long-term, however, the tic-reducing effects are outweighed by the side effects. Therefore, we switched to globus pallidus stimulation, which is shown to have marked short-term and long-term tic-reducing effects.
Original language | English |
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Awarding Institution |
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Award date | 1 Jun 2018 |
Place of Publication | Maastricht |
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Print ISBNs | 9789461598196 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- deep brain stimulation
- Gilles de la Tourette