New insights in deep brain stimulation for Tourette syndrome

Research output: ThesisDoctoral ThesisInternal

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This thesis describes new insights into deep brain stimulation in otherwise treatment-resistant patients with Tourette Syndrome. Although the exact cause of Tourette Syndrome is largely unknown, it is shown that basal ganglia dysfunction plays a role. Deep brain stimulation activates certain areas within the basal ganglia. We found that thalamus stimulation has marked short-term tic-reducing effects. In the long-term, however, the tic-reducing effects are outweighed by the side effects. Therefore, we switched to globus pallidus stimulation, which is shown to have marked short-term and long-term tic-reducing effects.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Temel, Yasin, Supervisor
  • Ackermans, Linda, Co-Supervisor
  • Duits, Annelien, Co-Supervisor
  • Leentjens, Albert, Co-Supervisor
Award date1 Jun 2018
Place of PublicationMaastricht
Print ISBNs9789461598196
Publication statusPublished - 2018


  • deep brain stimulation
  • Gilles de la Tourette

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