Neutrophils as protagonists and targets in chronic inflammation

Oliver Soehnlein; Sabine Steffens; Andres Hidalgo; Christian Weber

doi:10.1038/nri.2017.10

Neutrophils as protagonists and targets in chronic inflammation

Oliver Soehnlein^*, Sabine Steffens, Andres Hidalgo, Christian Weber^*

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.

Original language	English
Pages (from-to)	248-261
Number of pages	14
Journal	Nature Reviews Immunology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1038/nri.2017.10
Publication status	Published - Apr 2017

Keywords

PLASMACYTOID DENDRITIC CELLS
COLONY-STIMULATING FACTOR
DIET-INDUCED OBESITY
ACUTE LUNG INJURY
EXTRACELLULAR TRAPS
HEMATOPOIETIC STEM
INSULIN-RESISTANCE
APOPTOTIC CELLS
MYOCARDIAL-INFARCTION
WOUND REPAIR

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10.1038/nri.2017.10

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title = "Neutrophils as protagonists and targets in chronic inflammation",

abstract = "Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.",

keywords = "PLASMACYTOID DENDRITIC CELLS, COLONY-STIMULATING FACTOR, DIET-INDUCED OBESITY, ACUTE LUNG INJURY, EXTRACELLULAR TRAPS, HEMATOPOIETIC STEM, INSULIN-RESISTANCE, APOPTOTIC CELLS, MYOCARDIAL-INFARCTION, WOUND REPAIR",

author = "Oliver Soehnlein and Sabine Steffens and Andres Hidalgo and Christian Weber",

year = "2017",

month = apr,

doi = "10.1038/nri.2017.10",

language = "English",

volume = "17",

pages = "248--261",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Publishing Group",

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T1 - Neutrophils as protagonists and targets in chronic inflammation

AU - Soehnlein, Oliver

AU - Steffens, Sabine

AU - Hidalgo, Andres

AU - Weber, Christian

PY - 2017/4

Y1 - 2017/4

N2 - Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.

AB - Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.

KW - PLASMACYTOID DENDRITIC CELLS

KW - COLONY-STIMULATING FACTOR

KW - DIET-INDUCED OBESITY

KW - ACUTE LUNG INJURY

KW - EXTRACELLULAR TRAPS

KW - HEMATOPOIETIC STEM

KW - INSULIN-RESISTANCE

KW - APOPTOTIC CELLS

KW - MYOCARDIAL-INFARCTION

KW - WOUND REPAIR

U2 - 10.1038/nri.2017.10

DO - 10.1038/nri.2017.10

M3 - (Systematic) Review article

C2 - 28287106

SN - 1474-1733

VL - 17

SP - 248

EP - 261

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 4

ER -

Neutrophils as protagonists and targets in chronic inflammation

Abstract

Keywords

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