Neutrophils as protagonists and targets in chronic inflammation

Oliver Soehnlein*, Sabine Steffens, Andres Hidalgo, Christian Weber*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

272 Citations (Web of Science)

Abstract

Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.

Original languageEnglish
Pages (from-to)248-261
Number of pages14
JournalNature Reviews Immunology
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • PLASMACYTOID DENDRITIC CELLS
  • COLONY-STIMULATING FACTOR
  • DIET-INDUCED OBESITY
  • ACUTE LUNG INJURY
  • EXTRACELLULAR TRAPS
  • HEMATOPOIETIC STEM
  • INSULIN-RESISTANCE
  • APOPTOTIC CELLS
  • MYOCARDIAL-INFARCTION
  • WOUND REPAIR

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