Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints

Kete M Klaver; Saskia F A Duijts; Chantal A V Geusgens; Maureen J B Aarts; Rudolf W H M Ponds; Allard J van der Beek; Sanne B Schagen

doi:10.1007/s11764-022-01223-x

Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints

Kete M Klaver, Saskia F A Duijts, Chantal A V Geusgens, Maureen J B Aarts, Rudolf W H M Ponds, Allard J van der Beek, Sanne B Schagen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: To assess cognitive functioning in occupationally active non-central nervous system cancer survivors with cognitive complaints using neuropsychological tests, and to investigate the association between (1) formally assessed cognitive functioning and self-reported work-related outcomes and (2) self-reported cognitive functioning at work and self-reported work-related outcomes.

METHODS: Baseline data of a multicenter, randomized controlled trial (n = 279) were used. Associations between neuropsychological test performance (Amsterdam Cognition Scan) and self-reported cognitive functioning (Cognitive Symptom Checklist-work) with work ability (Work Ability Index) and work functioning (Work Role Functioning Questionnaire) were examined using multivariate linear regression.

RESULTS: Thirty percent of cancer survivors had lower than expected performance on neuropsychological tests. Higher overall neuropsychological test performance was associated with better work ability (Cohen's f2 = 0.014) and physical functioning at work (Cohen's f2 = 0.13). Furthermore, higher motor performance was associated with better work ability (Cohen's f2 = 0.018). In addition, self-reported work-related cognitive complaints were associated with self-reported work-related outcomes (Cohen's f2 = 0.13-0.35).

CONCLUSIONS: The percentage of cancer survivors with lower than expected performance on neuropsychological tests exceeded the percentage expected in a normal population. This neuropsychological test performance was weakly associated with various aspects of work ability and work functioning. Stronger associations were found between self-reported cognitive functioning at work with self-reported work-related outcomes.

IMPLICATIONS FOR CANCER SURVIVORS: A cognitive rehabilitation approach that specifically aims at reducing cognitive symptoms at work could be a valuable part of interventions that aim to improve work-related outcomes. Trial registration The study is registered at ClinicalTrials.gov (NCT03900806) at 03 April 2019 (current status: ongoing), https://clinicaltrials.gov/ct2/show/NCT03900806?term=NCT03900806&draw=2&rank=1.

Original language	English
Number of pages	13
Journal	Journal of Cancer Survivorship-Research and Practice
DOIs	https://doi.org/10.1007/s11764-022-01223-x
Publication status	E-pub ahead of print - 1 Jul 2022

Keywords

ABILITY
Cancer-related cognitive impairment
EMPLOYMENT
Employment
FATIGUE
HEALTH
IMPAIRMENT
MANAGEMENT
Neuropsychological test performance
RETURN
WOMEN
Work ability
Work functioning

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10.1007/s11764-022-01223-x

Cite this

Klaver, K. M., Duijts, S. F. A., Geusgens, C. A. V., Aarts, M. J. B., Ponds, R. W. H. M., van der Beek, A. J., & Schagen, S. B. (2022). Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints. Journal of Cancer Survivorship-Research and Practice. Advance online publication. https://doi.org/10.1007/s11764-022-01223-x

@article{f6ceac28a22140ecbaa9d3e144a86e82,

title = "Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints",

abstract = "PURPOSE: To assess cognitive functioning in occupationally active non-central nervous system cancer survivors with cognitive complaints using neuropsychological tests, and to investigate the association between (1) formally assessed cognitive functioning and self-reported work-related outcomes and (2) self-reported cognitive functioning at work and self-reported work-related outcomes.METHODS: Baseline data of a multicenter, randomized controlled trial (n = 279) were used. Associations between neuropsychological test performance (Amsterdam Cognition Scan) and self-reported cognitive functioning (Cognitive Symptom Checklist-work) with work ability (Work Ability Index) and work functioning (Work Role Functioning Questionnaire) were examined using multivariate linear regression.RESULTS: Thirty percent of cancer survivors had lower than expected performance on neuropsychological tests. Higher overall neuropsychological test performance was associated with better work ability (Cohen's f2 = 0.014) and physical functioning at work (Cohen's f2 = 0.13). Furthermore, higher motor performance was associated with better work ability (Cohen's f2 = 0.018). In addition, self-reported work-related cognitive complaints were associated with self-reported work-related outcomes (Cohen's f2 = 0.13-0.35).CONCLUSIONS: The percentage of cancer survivors with lower than expected performance on neuropsychological tests exceeded the percentage expected in a normal population. This neuropsychological test performance was weakly associated with various aspects of work ability and work functioning. Stronger associations were found between self-reported cognitive functioning at work with self-reported work-related outcomes.IMPLICATIONS FOR CANCER SURVIVORS: A cognitive rehabilitation approach that specifically aims at reducing cognitive symptoms at work could be a valuable part of interventions that aim to improve work-related outcomes. Trial registration The study is registered at ClinicalTrials.gov (NCT03900806) at 03 April 2019 (current status: ongoing), https://clinicaltrials.gov/ct2/show/NCT03900806?term=NCT03900806&draw=2&rank=1.",

keywords = "ABILITY, Cancer-related cognitive impairment, EMPLOYMENT, Employment, FATIGUE, HEALTH, IMPAIRMENT, MANAGEMENT, Neuropsychological test performance, RETURN, WOMEN, Work ability, Work functioning",

author = "Klaver, {Kete M} and Duijts, {Saskia F A} and Geusgens, {Chantal A V} and Aarts, {Maureen J B} and Ponds, {Rudolf W H M} and {van der Beek}, {Allard J} and Schagen, {Sanne B}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = jul,

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doi = "10.1007/s11764-022-01223-x",

language = "English",

journal = "Journal of Cancer Survivorship-Research and Practice",

issn = "1932-2259",

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Klaver, KM, Duijts, SFA, Geusgens, CAV, Aarts, MJB, Ponds, RWHM, van der Beek, AJ & Schagen, SB 2022, 'Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints', Journal of Cancer Survivorship-Research and Practice. https://doi.org/10.1007/s11764-022-01223-x

Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints. / Klaver, Kete M; Duijts, Saskia F A; Geusgens, Chantal A V et al.
In: Journal of Cancer Survivorship-Research and Practice, 01.07.2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints

AU - Klaver, Kete M

AU - Duijts, Saskia F A

AU - Geusgens, Chantal A V

AU - Aarts, Maureen J B

AU - Ponds, Rudolf W H M

AU - van der Beek, Allard J

AU - Schagen, Sanne B

PY - 2022/7/1

Y1 - 2022/7/1

N2 - PURPOSE: To assess cognitive functioning in occupationally active non-central nervous system cancer survivors with cognitive complaints using neuropsychological tests, and to investigate the association between (1) formally assessed cognitive functioning and self-reported work-related outcomes and (2) self-reported cognitive functioning at work and self-reported work-related outcomes.METHODS: Baseline data of a multicenter, randomized controlled trial (n = 279) were used. Associations between neuropsychological test performance (Amsterdam Cognition Scan) and self-reported cognitive functioning (Cognitive Symptom Checklist-work) with work ability (Work Ability Index) and work functioning (Work Role Functioning Questionnaire) were examined using multivariate linear regression.RESULTS: Thirty percent of cancer survivors had lower than expected performance on neuropsychological tests. Higher overall neuropsychological test performance was associated with better work ability (Cohen's f2 = 0.014) and physical functioning at work (Cohen's f2 = 0.13). Furthermore, higher motor performance was associated with better work ability (Cohen's f2 = 0.018). In addition, self-reported work-related cognitive complaints were associated with self-reported work-related outcomes (Cohen's f2 = 0.13-0.35).CONCLUSIONS: The percentage of cancer survivors with lower than expected performance on neuropsychological tests exceeded the percentage expected in a normal population. This neuropsychological test performance was weakly associated with various aspects of work ability and work functioning. Stronger associations were found between self-reported cognitive functioning at work with self-reported work-related outcomes.IMPLICATIONS FOR CANCER SURVIVORS: A cognitive rehabilitation approach that specifically aims at reducing cognitive symptoms at work could be a valuable part of interventions that aim to improve work-related outcomes. Trial registration The study is registered at ClinicalTrials.gov (NCT03900806) at 03 April 2019 (current status: ongoing), https://clinicaltrials.gov/ct2/show/NCT03900806?term=NCT03900806&draw=2&rank=1.

AB - PURPOSE: To assess cognitive functioning in occupationally active non-central nervous system cancer survivors with cognitive complaints using neuropsychological tests, and to investigate the association between (1) formally assessed cognitive functioning and self-reported work-related outcomes and (2) self-reported cognitive functioning at work and self-reported work-related outcomes.METHODS: Baseline data of a multicenter, randomized controlled trial (n = 279) were used. Associations between neuropsychological test performance (Amsterdam Cognition Scan) and self-reported cognitive functioning (Cognitive Symptom Checklist-work) with work ability (Work Ability Index) and work functioning (Work Role Functioning Questionnaire) were examined using multivariate linear regression.RESULTS: Thirty percent of cancer survivors had lower than expected performance on neuropsychological tests. Higher overall neuropsychological test performance was associated with better work ability (Cohen's f2 = 0.014) and physical functioning at work (Cohen's f2 = 0.13). Furthermore, higher motor performance was associated with better work ability (Cohen's f2 = 0.018). In addition, self-reported work-related cognitive complaints were associated with self-reported work-related outcomes (Cohen's f2 = 0.13-0.35).CONCLUSIONS: The percentage of cancer survivors with lower than expected performance on neuropsychological tests exceeded the percentage expected in a normal population. This neuropsychological test performance was weakly associated with various aspects of work ability and work functioning. Stronger associations were found between self-reported cognitive functioning at work with self-reported work-related outcomes.IMPLICATIONS FOR CANCER SURVIVORS: A cognitive rehabilitation approach that specifically aims at reducing cognitive symptoms at work could be a valuable part of interventions that aim to improve work-related outcomes. Trial registration The study is registered at ClinicalTrials.gov (NCT03900806) at 03 April 2019 (current status: ongoing), https://clinicaltrials.gov/ct2/show/NCT03900806?term=NCT03900806&draw=2&rank=1.

KW - ABILITY

KW - Cancer-related cognitive impairment

KW - EMPLOYMENT

KW - Employment

KW - FATIGUE

KW - HEALTH

KW - IMPAIRMENT

KW - MANAGEMENT

KW - Neuropsychological test performance

KW - RETURN

KW - WOMEN

KW - Work ability

KW - Work functioning

U2 - 10.1007/s11764-022-01223-x

DO - 10.1007/s11764-022-01223-x

M3 - Article

C2 - 35776235

SN - 1932-2259

JO - Journal of Cancer Survivorship-Research and Practice

JF - Journal of Cancer Survivorship-Research and Practice

ER -

Klaver KM, Duijts SFA, Geusgens CAV, Aarts MJB, Ponds RWHM, van der Beek AJ et al. Neuropsychological test performance and self-reported cognitive functioning associated with work-related outcomes in occupationally active cancer survivors with cognitive complaints. Journal of Cancer Survivorship-Research and Practice. 2022 Jul 1. Epub 2022 Jul 1. doi: 10.1007/s11764-022-01223-x