Neuromuscular Control before and after Independent Walking Onset in Children with Cerebral Palsy

A. Bekius, C.S. Zandvoort, J.N. Kerkman, L.A. van de Pol, R.J. Vermeulen, J. Harlaar, A. Daffertshofer, A.I. Buizer, N. Dominici*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Early brain lesions which produce cerebral palsy (CP) may affect the development of walking. It is unclear whether or how neuromuscular control, as evaluated by muscle synergy analysis, differs in young children with CP compared to typically developing (TD) children with the same walking ability, before and after the onset of independent walking. Here we grouped twenty children with (high risk of) CP and twenty TD children (age 6.5-52.4 months) based on their walking ability, supported or independent walking. Muscle synergies were extracted from electromyography data of bilateral leg muscles using non-negative matrix factorization. Number, synergies' structure and variability accounted for when extracting one (VAF(1)) or two (VAF(2)) synergies were compared between CP and TD. Children in the CP group recruited fewer synergies with higher VAF(1) and VAF(2) compared to TD children in the supported and independent walking group. The most affected side in children with asymmetric CP walking independently recruited fewer synergies with higher VAF(1) compared to the least affected side. Our findings suggest that early brain lesions result in early alterations of neuromuscular control, specific for the most affected side in asymmetric CP.
Original languageEnglish
Article number2714
Number of pages13
JournalSensors
Volume21
Issue number8
DOIs
Publication statusPublished - 1 Apr 2021

Keywords

  • muscle synergies
  • CP
  • electromyography
  • gait
  • early brain lesions
  • motor development
  • MUSCLE ACTIVATION PATTERNS
  • TYPICALLY DEVELOPING-CHILDREN
  • MOTOR CONTROL
  • HIGH-RISK
  • SYNERGIES
  • GAIT
  • COMPLEXITY
  • CLASSIFICATION
  • REPEATABILITY
  • INTERVENTION

Cite this