Neuroimaging standards for research into small vessel disease-advances since 2013

Marco Duering; Geert Jan Biessels; Amy Brodtmann; Christopher Chen; Charlotte Cordonnier; Frank-Erik de Leeuw; Stephanie Debette; Richard Frayne; Eric Jouvent; Natalia S. Rost; Annemieke ter Telgte; Rustam Al-Shahi Salman; Walter H. Backes; Hee-Joon Bae; Rosalind Brown; Hugues Chabriat; Alberto De Luca; Charles deCarli; Anna Dewenter; Fergus N. Doubal; Michael Ewers; Thalia S. Field; Aravind Ganesh; Steven Greenberg; Karl G. Helmer; Saima Hilal; Angela C. C. Jochems; Hanna Jokinen; Hugo Kuijf; Bonnie Y. K. Lam; Jessica Lebenberg; Bradley J. MacIntosh; Pauline Maillard; Vincent C. T. Mok; Leonardo Pantoni; Salvatore Rudilosso; Claudia L. Satizabal; Markus D. Schirmer; Reinhold Schmidt; Colin Smith; Julie Staals; Michael J. Thrippleton; Susanne J. van Veluw; Prashanthi Vemuri; Yilong Wang; David Werring; Marialuisa Zedde; Rufus O. Akinyemi; Oscar H. Del Brutto; Hugh S. Markus; Et al.

doi:10.1016/S1474-4422(23)00131-X

Neuroimaging standards for research into small vessel disease-advances since 2013

Marco Duering^*, Geert Jan Biessels, Amy Brodtmann, Christopher Chen, Charlotte Cordonnier, Frank-Erik de Leeuw, Stephanie Debette, Richard Frayne, Eric Jouvent, Natalia S. Rost, Annemieke ter Telgte, Rustam Al-Shahi Salman, Walter H. Backes, Hee-Joon Bae, Rosalind Brown, Hugues Chabriat, Alberto De Luca, Charles deCarli, Anna Dewenter, Fergus N. DoubalMichael Ewers, Thalia S. Field, Aravind Ganesh, Steven Greenberg, Karl G. Helmer, Saima Hilal, Angela C. C. Jochems, Hanna Jokinen, Hugo Kuijf, Bonnie Y. K. Lam, Jessica Lebenberg, Bradley J. MacIntosh, Pauline Maillard, Vincent C. T. Mok, Leonardo Pantoni, Salvatore Rudilosso, Claudia L. Satizabal, Markus D. Schirmer, Reinhold Schmidt, Colin Smith, Julie Staals, Michael J. Thrippleton, Susanne J. van Veluw, Prashanthi Vemuri, Yilong Wang, David Werring, Marialuisa Zedde, Rufus O. Akinyemi, Oscar H. Del Brutto, Hugh S. Markus, Et al.

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.

Original language	English
Pages (from-to)	602-618
Number of pages	17
Journal	Lancet Neurology
Volume	22
Issue number	7
Early online date	1 Jun 2023
DOIs	https://doi.org/10.1016/S1474-4422(23)00131-X
Publication status	Published - 1 Jul 2023

Keywords

WHITE-MATTER HYPERINTENSITIES
CEREBRAL AMYLOID ANGIOPATHY
PERIVASCULAR SPACES
RISK-FACTORS
DIFFUSION MRI
BRAIN
MICROBLEEDS
BURDEN
LACUNE
CORTEX

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Duering, M., Biessels, G. J., Brodtmann, A., Chen, C., Cordonnier, C., de Leeuw, F.-E., Debette, S., Frayne, R., Jouvent, E., Rost, N. S., ter Telgte, A., Salman, R. A.-S., Backes, W. H., Bae, H.-J., Brown, R., Chabriat, H., De Luca, A., deCarli, C., Dewenter, A., ... Et al. (2023). Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurology, 22(7), 602-618. https://doi.org/10.1016/S1474-4422(23)00131-X

@article{381b0909eb0e49b19a4d26339a7cbf2b,

title = "Neuroimaging standards for research into small vessel disease-advances since 2013",

abstract = "Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.",

keywords = "WHITE-MATTER HYPERINTENSITIES, CEREBRAL AMYLOID ANGIOPATHY, PERIVASCULAR SPACES, RISK-FACTORS, DIFFUSION MRI, BRAIN, MICROBLEEDS, BURDEN, LACUNE, CORTEX",

author = "Marco Duering and Biessels, {Geert Jan} and Amy Brodtmann and Christopher Chen and Charlotte Cordonnier and {de Leeuw}, Frank-Erik and Stephanie Debette and Richard Frayne and Eric Jouvent and Rost, {Natalia S.} and {ter Telgte}, Annemieke and Salman, {Rustam Al-Shahi} and Backes, {Walter H.} and Hee-Joon Bae and Rosalind Brown and Hugues Chabriat and {De Luca}, Alberto and Charles deCarli and Anna Dewenter and Doubal, {Fergus N.} and Michael Ewers and Field, {Thalia S.} and Aravind Ganesh and Steven Greenberg and Helmer, {Karl G.} and Saima Hilal and Jochems, {Angela C. C.} and Hanna Jokinen and Hugo Kuijf and Lam, {Bonnie Y. K.} and Jessica Lebenberg and MacIntosh, {Bradley J.} and Pauline Maillard and Mok, {Vincent C. T.} and Leonardo Pantoni and Salvatore Rudilosso and Satizabal, {Claudia L.} and Schirmer, {Markus D.} and Reinhold Schmidt and Colin Smith and Julie Staals and Thrippleton, {Michael J.} and {van Veluw}, {Susanne J.} and Prashanthi Vemuri and Yilong Wang and David Werring and Marialuisa Zedde and Akinyemi, {Rufus O.} and {Del Brutto}, {Oscar H.} and Markus, {Hugh S.} and {Et al.}",

year = "2023",

month = jul,

day = "1",

doi = "10.1016/S1474-4422(23)00131-X",

language = "English",

volume = "22",

pages = "602--618",

journal = "Lancet Neurology",

issn = "1474-4422",

publisher = "Elsevier Science",

number = "7",

}

Duering, M, Biessels, GJ, Brodtmann, A, Chen, C, Cordonnier, C, de Leeuw, F-E, Debette, S, Frayne, R, Jouvent, E, Rost, NS, ter Telgte, A, Salman, RA-S, Backes, WH, Bae, H-J, Brown, R, Chabriat, H, De Luca, A, deCarli, C, Dewenter, A, Doubal, FN, Ewers, M, Field, TS, Ganesh, A, Greenberg, S, Helmer, KG, Hilal, S, Jochems, ACC, Jokinen, H, Kuijf, H, Lam, BYK, Lebenberg, J, MacIntosh, BJ, Maillard, P, Mok, VCT, Pantoni, L, Rudilosso, S, Satizabal, CL, Schirmer, MD, Schmidt, R, Smith, C, Staals, J, Thrippleton, MJ, van Veluw, SJ, Vemuri, P, Wang, Y, Werring, D, Zedde, M, Akinyemi, RO, Del Brutto, OH, Markus, HS & Et al. 2023, 'Neuroimaging standards for research into small vessel disease-advances since 2013', Lancet Neurology, vol. 22, no. 7, pp. 602-618. https://doi.org/10.1016/S1474-4422(23)00131-X

TY - JOUR

T1 - Neuroimaging standards for research into small vessel disease-advances since 2013

AU - Duering, Marco

AU - Biessels, Geert Jan

AU - Brodtmann, Amy

AU - Chen, Christopher

AU - Cordonnier, Charlotte

AU - de Leeuw, Frank-Erik

AU - Debette, Stephanie

AU - Frayne, Richard

AU - Jouvent, Eric

AU - Rost, Natalia S.

AU - ter Telgte, Annemieke

AU - Salman, Rustam Al-Shahi

AU - Backes, Walter H.

AU - Bae, Hee-Joon

AU - Brown, Rosalind

AU - Chabriat, Hugues

AU - De Luca, Alberto

AU - deCarli, Charles

AU - Dewenter, Anna

AU - Doubal, Fergus N.

AU - Ewers, Michael

AU - Field, Thalia S.

AU - Ganesh, Aravind

AU - Greenberg, Steven

AU - Helmer, Karl G.

AU - Hilal, Saima

AU - Jochems, Angela C. C.

AU - Jokinen, Hanna

AU - Kuijf, Hugo

AU - Lam, Bonnie Y. K.

AU - Lebenberg, Jessica

AU - MacIntosh, Bradley J.

AU - Maillard, Pauline

AU - Mok, Vincent C. T.

AU - Pantoni, Leonardo

AU - Rudilosso, Salvatore

AU - Satizabal, Claudia L.

AU - Schirmer, Markus D.

AU - Schmidt, Reinhold

AU - Smith, Colin

AU - Staals, Julie

AU - Thrippleton, Michael J.

AU - van Veluw, Susanne J.

AU - Vemuri, Prashanthi

AU - Wang, Yilong

AU - Werring, David

AU - Zedde, Marialuisa

AU - Akinyemi, Rufus O.

AU - Del Brutto, Oscar H.

AU - Markus, Hugh S.

AU - Et al.

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.

AB - Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.

KW - WHITE-MATTER HYPERINTENSITIES

KW - CEREBRAL AMYLOID ANGIOPATHY

KW - PERIVASCULAR SPACES

KW - RISK-FACTORS

KW - DIFFUSION MRI

KW - BRAIN

KW - MICROBLEEDS

KW - BURDEN

KW - LACUNE

KW - CORTEX

U2 - 10.1016/S1474-4422(23)00131-X

DO - 10.1016/S1474-4422(23)00131-X

M3 - (Systematic) Review article

C2 - 37236211

SN - 1474-4422

VL - 22

SP - 602

EP - 618

JO - Lancet Neurology

JF - Lancet Neurology

IS - 7

ER -

Neuroimaging standards for research into small vessel disease-advances since 2013

Abstract

Keywords

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