NAFLD Preclinical Models: More than a Handful, Less of a Concern?

Yvonne Oligschlaeger*, Ronit Shiri-Sverdlov

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Web of Science)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and/or hepatocellular carcinoma. Due to its increasing prevalence, NAFLD is currently a major public health concern. Although a wide variety of preclinical models have contributed to better understanding the pathophysiology of NAFLD, it is not always obvious which model is best suitable for addressing a specific research question. This review provides insights into currently existing models, mainly focusing on murine models, which is of great importance to aid in the identification of novel therapeutic options for human NAFLD.

Original languageEnglish
Article number28
Number of pages23
JournalBiomedicines
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • NAFLD
  • mouse models
  • multifactorial disease
  • translational value
  • FATTY LIVER-DISEASE
  • ACTIVATED RECEPTOR-ALPHA
  • CHOLINE-DEFICIENT DIET
  • NONALCOHOLIC STEATOHEPATITIS
  • MOUSE MODELS
  • HEPATOCELLULAR-CARCINOMA
  • HEPATIC STEATOSIS
  • CONFERS SUSCEPTIBILITY
  • METABOLIC SYNDROME
  • PROSTAGLANDIN E-2

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