Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review

W.A.J. Vints; O. Levin; N. Masiulis; J. Verbunt; C.C.M. van Laake-Geelen

doi:10.1016/j.neubiorev.2023.105065

Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review

W.A.J. Vints^*, O. Levin, N. Masiulis, J. Verbunt, C.C.M. van Laake-Geelen

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.

Original language	English
Article number	105065
Number of pages	16
Journal	Neuroscience and Biobehavioral Reviews
Volume	146
Issue number	1
DOIs	https://doi.org/10.1016/j.neubiorev.2023.105065
Publication status	Published - 1 Mar 2023

Keywords

Rehabilitation
Myokine
Neuroplasticity
Inflammation
Exercise
Neurotrophic factor
Spinal cord injury
Cognition
TRAUMATIC BRAIN-INJURY
NEUROTROPHIC FACTOR
SLEEP-APNEA
CARDIOVASCULAR-DISEASE
SYNAPTIC PLASTICITY
ALZHEIMERS-DISEASE
CYTOKINE RESPONSE
OLDER-ADULTS
RISK-FACTORS
EXERCISE

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Cite this

@article{7c266180d38840639e7dcc4c483be6f3,

title = "Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review",

abstract = "Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.",

keywords = "Rehabilitation, Myokine, Neuroplasticity, Inflammation, Exercise, Neurotrophic factor, Spinal cord injury, Cognition, TRAUMATIC BRAIN-INJURY, NEUROTROPHIC FACTOR, SLEEP-APNEA, CARDIOVASCULAR-DISEASE, SYNAPTIC PLASTICITY, ALZHEIMERS-DISEASE, CYTOKINE RESPONSE, OLDER-ADULTS, RISK-FACTORS, EXERCISE",

author = "W.A.J. Vints and O. Levin and N. Masiulis and J. Verbunt and {van Laake-Geelen}, C.C.M.",

note = "Funding Information: This work was supported by the Research Council of Lithuania , Lithuania (Lietuvos mokslo taryba) under Grant number S-MIP-21–37 . The sponsor was not involved in study design; collection, analysis and interpretation of the data; in writing of the report; nor in the decision to submit the article for publication. Funding Information: This work was supported by the Research Council of Lithuania, Lithuania (Lietuvos mokslo taryba) under Grant number S-MIP-21–37. The sponsor was not involved in study design; collection, analysis and interpretation of the data; in writing of the report; nor in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = mar,

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doi = "10.1016/j.neubiorev.2023.105065",

language = "English",

volume = "146",

journal = "Neuroscience and Biobehavioral Reviews",

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T1 - Myokines may target accelerated cognitive aging in people with spinal cord injury: A systematic and topical review

AU - Vints, W.A.J.

AU - Levin, O.

AU - Masiulis, N.

AU - Verbunt, J.

AU - van Laake-Geelen, C.C.M.

N1 - Funding Information: This work was supported by the Research Council of Lithuania , Lithuania (Lietuvos mokslo taryba) under Grant number S-MIP-21–37 . The sponsor was not involved in study design; collection, analysis and interpretation of the data; in writing of the report; nor in the decision to submit the article for publication. Funding Information: This work was supported by the Research Council of Lithuania, Lithuania (Lietuvos mokslo taryba) under Grant number S-MIP-21–37. The sponsor was not involved in study design; collection, analysis and interpretation of the data; in writing of the report; nor in the decision to submit the article for publication. Publisher Copyright: © 2023 The Authors

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.

AB - Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.

KW - Rehabilitation

KW - Myokine

KW - Neuroplasticity

KW - Inflammation

KW - Exercise

KW - Neurotrophic factor

KW - Spinal cord injury

KW - Cognition

KW - TRAUMATIC BRAIN-INJURY

KW - NEUROTROPHIC FACTOR

KW - SLEEP-APNEA

KW - CARDIOVASCULAR-DISEASE

KW - SYNAPTIC PLASTICITY

KW - ALZHEIMERS-DISEASE

KW - CYTOKINE RESPONSE

KW - OLDER-ADULTS

KW - RISK-FACTORS

KW - EXERCISE

U2 - 10.1016/j.neubiorev.2023.105065

DO - 10.1016/j.neubiorev.2023.105065

M3 - (Systematic) Review article

C2 - 36716905

SN - 0149-7634

VL - 146

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

IS - 1

M1 - 105065

ER -