Myocardial Fatty Acid-Glucose Fuel Balance as Target to Treat Cardiac Diseases

Jan Glatz*, Miranda Nabben, Joannes Luiken

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


The currently most prevalent cardiac diseases, diabetic cardiomyopathy and hypertrophic heart failure, each associate with a chronic change in energy substrate utilization towards a single type of substrate, i.e., fatty acids or glucose, respectively. Recent experimental studies suggest that proper cardiac contractile performance is dependent on a finely tuned balance between the utilization of these two substrates. Furthermore, re-balancing myocardial fuel supply (fatty acids versus glucose) appears an effective treatment option in cardiac disease.
Original languageEnglish
Pages (from-to)584-590
Number of pages7
JournalCardiology and Cardiovascular Medicine
Issue number5
Publication statusPublished - 2020

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