TY - JOUR
T1 - Myocardial Fatty Acid-Glucose Fuel Balance as Target to Treat Cardiac Diseases
AU - Glatz, Jan
AU - Nabben, Miranda
AU - Luiken, Joannes
PY - 2020
Y1 - 2020
N2 - The currently most prevalent cardiac diseases, diabetic cardiomyopathy and hypertrophic heart failure, each associate with a chronic change in energy substrate utilization towards a single type of substrate, i.e., fatty acids or glucose, respectively. Recent experimental studies suggest that proper cardiac contractile performance is dependent on a finely tuned balance between the utilization of these two substrates. Furthermore, re-balancing myocardial fuel supply (fatty acids versus glucose) appears an effective treatment option in cardiac disease.
AB - The currently most prevalent cardiac diseases, diabetic cardiomyopathy and hypertrophic heart failure, each associate with a chronic change in energy substrate utilization towards a single type of substrate, i.e., fatty acids or glucose, respectively. Recent experimental studies suggest that proper cardiac contractile performance is dependent on a finely tuned balance between the utilization of these two substrates. Furthermore, re-balancing myocardial fuel supply (fatty acids versus glucose) appears an effective treatment option in cardiac disease.
U2 - 10.26502/fccm.92920154
DO - 10.26502/fccm.92920154
M3 - (Systematic) Review article
SN - 2572-9292
VL - 4
SP - 584
EP - 590
JO - Cardiology and Cardiovascular Medicine
JF - Cardiology and Cardiovascular Medicine
IS - 5
ER -