Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle

Swati S. Jain; Laelie A. Snook; Jan F. C. Glatz; Joost J. F. P. Luiken; Graham P. Holloway; Debbie C. Thurmond; Arend Bonen

doi:10.1016/j.febslet.2012.05.061

Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle

Swati S. Jain, Laelie A. Snook, Jan F. C. Glatz, Joost J. F. P. Luiken, Graham P. Holloway, Debbie C. Thurmond, Arend Bonen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Insulin-, and contraction-induced GLUT4 and fatty acid (FA) transporter translocation may share common trafficking mechanisms. Our objective was to examine the effects of partial Munc18c ablation on muscle glucose and FA transport, FA oxidation, GLUT4 and FA transporter (FAT/CD36, FAB-Ppm, FATP1, FATP4) trafficking to the sarcolemma, and FAT/CD36 to mitochondria. In Munc18c(-/+) mice, insulin-stimulated glucose transport and GLUT4 sarcolemmal appearance were impaired, but were unaffected by contraction. Insulin- and contraction-stimulated FA transport, sarcolemmal FA transporter appearance, and contraction-mediated mitochondrial FAT/CD36 were increased normally in Munc18c(-/+) mice. Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking.

Original language	English
Pages (from-to)	2428-2435
Journal	Febs Letters
Volume	586
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2012.05.061
Publication status	Published - 30 Jul 2012

Keywords

FAT/CD36
FABPpm
FATP1
FATP4
Fatty acid transport
Glucose transport

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10.1016/j.febslet.2012.05.061

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title = "Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle",

abstract = "Insulin-, and contraction-induced GLUT4 and fatty acid (FA) transporter translocation may share common trafficking mechanisms. Our objective was to examine the effects of partial Munc18c ablation on muscle glucose and FA transport, FA oxidation, GLUT4 and FA transporter (FAT/CD36, FAB-Ppm, FATP1, FATP4) trafficking to the sarcolemma, and FAT/CD36 to mitochondria. In Munc18c(-/+) mice, insulin-stimulated glucose transport and GLUT4 sarcolemmal appearance were impaired, but were unaffected by contraction. Insulin- and contraction-stimulated FA transport, sarcolemmal FA transporter appearance, and contraction-mediated mitochondrial FAT/CD36 were increased normally in Munc18c(-/+) mice. Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking. ",

keywords = "FAT/CD36, FABPpm, FATP1, FATP4, Fatty acid transport, Glucose transport",

author = "Jain, {Swati S.} and Snook, {Laelie A.} and Glatz, {Jan F. C.} and Luiken, {Joost J. F. P.} and Holloway, {Graham P.} and Thurmond, {Debbie C.} and Arend Bonen",

year = "2012",

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doi = "10.1016/j.febslet.2012.05.061",

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journal = "Febs Letters",

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T1 - Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle

AU - Jain, Swati S.

AU - Snook, Laelie A.

AU - Glatz, Jan F. C.

AU - Luiken, Joost J. F. P.

AU - Holloway, Graham P.

AU - Thurmond, Debbie C.

AU - Bonen, Arend

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Insulin-, and contraction-induced GLUT4 and fatty acid (FA) transporter translocation may share common trafficking mechanisms. Our objective was to examine the effects of partial Munc18c ablation on muscle glucose and FA transport, FA oxidation, GLUT4 and FA transporter (FAT/CD36, FAB-Ppm, FATP1, FATP4) trafficking to the sarcolemma, and FAT/CD36 to mitochondria. In Munc18c(-/+) mice, insulin-stimulated glucose transport and GLUT4 sarcolemmal appearance were impaired, but were unaffected by contraction. Insulin- and contraction-stimulated FA transport, sarcolemmal FA transporter appearance, and contraction-mediated mitochondrial FAT/CD36 were increased normally in Munc18c(-/+) mice. Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking.

AB - Insulin-, and contraction-induced GLUT4 and fatty acid (FA) transporter translocation may share common trafficking mechanisms. Our objective was to examine the effects of partial Munc18c ablation on muscle glucose and FA transport, FA oxidation, GLUT4 and FA transporter (FAT/CD36, FAB-Ppm, FATP1, FATP4) trafficking to the sarcolemma, and FAT/CD36 to mitochondria. In Munc18c(-/+) mice, insulin-stimulated glucose transport and GLUT4 sarcolemmal appearance were impaired, but were unaffected by contraction. Insulin- and contraction-stimulated FA transport, sarcolemmal FA transporter appearance, and contraction-mediated mitochondrial FAT/CD36 were increased normally in Munc18c(-/+) mice. Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking.

KW - FAT/CD36

KW - FABPpm

KW - FATP1

KW - FATP4

KW - Fatty acid transport

KW - Glucose transport

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DO - 10.1016/j.febslet.2012.05.061

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SN - 0014-5793

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EP - 2435

JO - Febs Letters

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