@article{d3dd8deabb7a4912b6ccad013d2be302,
title = "Multiple environmental exposures in early-life and allergy-related outcomes in childhood",
abstract = "Introduction: Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children.Material and Methods: Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6-11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM).Results: In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-isononyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy.Discussion: This first comprehensive and systematic analysis of many environmental exposures suggests that prenatal exposure to traffic-related variables, PMabs and phthalates are associated with rhinitis and itchy rash.",
keywords = "air-pollution, allergic disease, asthma, atopic-dermatitis, birth, childhood, cohort profile, eczema, environmental exposure, exposome, phthalate exposure, pregnancy, prenatal exposure, smoke exposure, traffic density, ECZEMA, TRAFFIC DENSITY, Exposome, ATOPIC-DERMATITIS, Childhood, ASTHMA, BIRTH, COHORT PROFILE, Environmental exposure, PRENATAL EXPOSURE, SMOKE EXPOSURE, Pregnancy, AIR-POLLUTION, PHTHALATE EXPOSURE, Allergic disease",
author = "B. Granum and B. Oftedal and L. Agier and V. Siroux and P. Bird and M. Casas and C. Warembourg and J. Wright and L. Chatzi and \{de Castro\}, M. and D. Donaire and R. Grazuleviciene and L.S. Haug and L. Maitre and O. Robinson and I. Tamayo-Uria and J. Urquiza and M. Nieuwenhuijsen and R. Slama and C. Thomsen and M. Vrijheid",
note = "Funding Information: This work was supported by the European Community{\textquoteright}s Seventh Framework Programme [grant agreement no 308333 —the HELIX project]; Instituto de Salud Carlos III; CIBERESP; Conselleria de Sanitat; Generalitat Valenciana; Department of Health of the Basque Government; Provincial Government of Gipuzkoa; Generalitat de Catalunya - CIRIT ; Lithuanian Agency for Science Innovation and Technology [grant number 6-04-2014\_31V-66 ]; Norwegian Ministry of Health and Care Services; Norwegian Ministry of Education and Research; Greek Ministry of Health; Ministerio de Ciencia Innovacion y Universidades [grant number MTM2015-68140-R ]; Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII; Fondation de France. Funding Information: We are grateful to all the participating families in the cohorts who took part in this study, especially the families that participated in the clinical examinations in the follow-up study. We are also grateful to all the fieldworkers for their dedication and efficiency in this study. We acknowledge the input of the HELIX consortium. The authors would like to thank (1) Sonia Brishoual, Angelique Serre and Michele Grosdenier (Poitiers Biobank, CRB BB-0033-00068, Poitiers, France) for biological sample management and Professor Frederic Millot (Principal Investigator), Elodie Migault, Manuela Boue and Sandy Bertin (Clinical Investigation Center, Inserm CIC1402, CHU de Poitiers, Poitiers, France) for planning and investigational actions; (2) Veronique Ferrand-Rigalleau, C?line Leger and Noella Gorry (CHU de Poitiers, Poitiers, France) for administrative assistance (EDEN); (3) Silvia Fochs, Nuria Pey, Cecilia Persavente and Susana Gross for field work, sample management and overall management in INMA; (4) Georgia Chalkiadaki and Danai Feida for biological sample management, to Eirini Michalaki, Mariza Kampouri, Anny Kyriklaki and Minas Iakovidis for field study performance and to Maria Fasoulaki for administrative assistance (RHEA); (5) Health professionals, and researchers who have made BiB happen, Eleonora P Uphoff for her role in data collection and Noortje Uphoff for her role in the planning of the manuscript; (6) Ingvild Essen and Jorunn Evandt for thorough field work, Heidi Marie Nordheim for biological sample management and the MoBa administrative unit (MoBa). This work was supported by the European Community's Seventh Framework Programme [grant agreement no 308333?the HELIX project]; Instituto de Salud Carlos III; CIBERESP; Conselleria de Sanitat; Generalitat Valenciana; Department of Health of the Basque Government; Provincial Government of Gipuzkoa; Generalitat de Catalunya-CIRIT; Lithuanian Agency for Science Innovation and Technology [grant number 6-04-2014\_31V-66]; Norwegian Ministry of Health and Care Services; Norwegian Ministry of Education and Research; Greek Ministry of Health; Ministerio de Ciencia Innovacion y Universidades [grant number MTM2015-68140-R]; Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII; Fondation de France. Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = nov,
day = "1",
doi = "10.1016/j.envint.2020.106038",
language = "English",
volume = "144",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Ltd",
}