Multicenter trans-Atlantic experience with fenestrated-branched endovascular aortic repair of chronic post-dissection thoracoabdominal aortic aneurysms

Mohamed A. Abdelhalim, Emanuel R. Tenorio, Gustavo S. Oderich, Stephan Haulon, Gasper Warren, Donald Adam, Martin Claridge, Talha Butt, Said Abisi, Nuno V. Dias, Tilo Kölbel, Enrico Gallitto, Mauro Gargiulo, Panos Gkoutzios, Giuseppe Panuccio, Marek Kuzniar, Kevin Mani, Barend M. Mees, Geert W. Schurink, Björn SonessonPaolo Spath, Anders Wanhainen, Andres Schanzer, Adam W. Beck, Darren B. Schneider, Carlos H. Timaran, Matthew Eagleton, Mark A. Farber, Bijan Modarai*, Multicenter International Aortic Research Group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: This multicenter international study aimed to describe outcomes of fenestrated-branched endovascular aortic repairs (FB-EVAR) in a cohort of patients treated for chronic post-dissection thoracoabdominal aortic aneurysms (PD-TAAAs). Methods: We reviewed the clinical data of all consecutive patients treated by FB-EVAR for repair of extent I to III PD-TAAAs in 16 centers from the United States and Europe (2008-2021). Data were extracted from institutional prospectively maintained databases and electronic patient records. All patients received off-the-shelf or patient-specific manufactured fenestrated-branched stent grafts. Endpoints were any cause mortality and major adverse events at 30 days, technical success, target artery (TA) patency, freedom from TA instability, minor (endovascular with <12 Fr sheath) and major (open or =12 Fr sheath) secondary interventions, patient survival, and freedom from aortic-related mortality (ARM). Results: A total of 246 patients (76% male; median age, 67 years [interquartile range, 61-73 years]) were treated for extent I (7%), extent II (55%), and extent III (35%) PD-TAAAs by FB-EVAR. The median aneurysm diameter was 65 mm (interquartile range, 59-73 mm). Eighteen patients (7%) were octogenarians, 212 (86%) were American Society of Anesthesiologists class =3, and 21 (9%) presented with contained ruptured or symptomatic aneurysms. There were 917 renal-mesenteric vessels targeted by 581 fenestrations (63%) and 336 directional branches (37%), with a mean of 3.7 vessels per patient. Technical success was 96%. Mortality and rate of major adverse events at 30 days was 3% and 28%, including disabling complications such as new onset dialysis in 1%, major stroke in 1%, and permanent paraplegia in 2%. Mean follow-up was 24 months. Kaplan-Meier (KM) estimated patient survival at 3 and 5 years was 79% ± 6% and 65% ± 10%. KM estimated freedom from ARM was 95% ± 3% and 93% ± 5% at the same intervals. Unplanned secondary interventions were needed in 94 patients (38%), including minor procedures in 64 (25%) and major procedures in 30 (12%). There was one conversion to open surgical repair (<1%). KM estimated freedom from any secondary intervention was 44% ± 9% at 5 years. KM estimated primary and secondary TA patency were 93% ± 2% and 96% ± 1% at 5 years, respectively. Conclusions: FB-EVAR for chronic PD-TAAAs was associated with high technical success and a low rate of mortality (3%) and disabling complications at 30 days. Although the procedure is effective in the prevention of ARM, patient survival was low at 5 years (65%), likely due to the significant comorbidities in this cohort of patients. Freedom from secondary interventions at 5 years was 44%, although most procedures were minor. The significant rate of reinterventions highlights the need for continued patient surveillance.
Original languageEnglish
Pages (from-to)854-862.e1
Number of pages10
JournalJournal of Vascular Surgery
Issue number4
Early online date2023
Publication statusPublished - Oct 2023


  • Aortic dissection
  • Branched
  • Fenestrated
  • Thoracoabdominal aortic aneurysm


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