MRI surveillance for the detection of local recurrence in rectal cancer after transanal endoscopic microsurgery

Britt J. P. Hupkens, Monique Maas*, Milou H. Martens, Willem M. L. L. G. Deserno, Jeroen W. A. Leijtens, Patty J. Nelemans, Frans C. H. Bakers, Doenja M. J. Lambregts, Geerard L. Beets, Regina G. H. Beets-Tan

*Corresponding author for this work

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Abstract

To evaluate diagnostic performance of follow-up MRI for detection of local recurrence of rectal cancer after transanal endoscopic microsurgery (TEM).

Between January 2006 and February 2014, 81 patients who underwent TEM were included. Two expert readers (R1 and R2), independently evaluated T2-weighted (T2W) MRI and diffusion-weighted (DWI) MRI for the detection of local recurrence, retrospectively, and recorded confidence on a five-point scale. Diagnostic performance of follow-up MRI was assessed using ROC-curve analysis and kappa statistics for the reproducibility between readers.

293 MRIs were performed, 203 included DWI. 18 (22%) patients developed a local recurrence: luminal 11, nodal two and both five. Areas under the curve (AUCs) for local recurrence detection were 0.72 (R1) and 0.80 (R2) for T2W-MRI. For DWI, AUCs were 0.70 (R1) and 0.89 (R2). For nodal recurrence AUCs were 0.72 (R1) and 0.80 (R2) for T2W-MRI. Reproducibility was good for T2W-MRI (kappa 0.68 for luminal and kappa 0.71 for nodal recurrence) and moderate for DWI (kappa 0.57). AUCs and reproducibility for recurrence detection increased during follow-up.

Follow-up with MRI after TEM for rectal cancer is feasible. Postoperative changes can be confusing at the first postoperative MRI, but during follow-up diagnostic performance and reproducibility increase.

aEuro cent Follow-up with MRI is feasible for follow-up after TEM for rectal cancer.

aEuro cent DWI-MRI is a useful addition to detect recurrences after TEM.

aEuro cent Postoperative changes can be confusing and can lead to underestimation of recurrence.

aEuro cent Appearance of intermediate signal at T2W-MRI is suspicious for recurrence.

aEuro cent Nodal staging remains challenging.

Original languageEnglish
Pages (from-to)4960-4969
Number of pages10
JournalEuropean Radiology
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Magnetic resonance imaging
  • Rectal neoplasms
  • Transanal endoscopic microsurgery
  • Follow-up
  • Diffusion-weighted magnetic resonance imaging
  • TERM-FOLLOW-UP
  • CHEMORADIOTHERAPY
  • CHEMORADIATION
  • EXPERIENCE
  • TEM

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