Mother's Own Milk and Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Eduardo Villamor-Martinez, Maria Pierro, Giacomo Cavallaro, Fabio Mosca, Eduardo Villamor-Martinez*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

22 Citations (Web of Science)

Abstract

Background: Bronchopulmonary dysplasia (BPD) is the most common complication of very preterm birth and can lead to lifelong health consequences. Optimal nutrition is a cornerstone in the prevention and treatment of BPD. In very preterm infants, mother's own milk (MOM) feeding is associated with lower risks of necrotizing enterocolitis, retinopathy of prematurity, and sepsis. Although several studies have shown that MOM may protect against BPD, a systematic analysis of the evidence has not been performed to date.

Methods: A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE, from their inception to 1 December 2017. Longitudinal studies comparing the incidence of BPD in preterm infants fed with exclusive MOM, MOM supplemented with pretermformula (PF), and/or exclusively fed with PF were selected. A random-effects model was used to calculate the Mantel Haenszel risk ratio (RR) and 95% confidence interval (CI).

Results: Fifteen studies met the inclusion criteria (4,984 infants, 1,416 BPD cases). Use of exclusive MOM feedings was associated with a significant reduction in the risk of BPD (RR 0.74, 95% CI 0.57-0.96, 5 studies). In contrast, meta-analysis could not demonstrate a significant effect on BPD risk when infants fed with more than 50% MOM were compared with infants fed with

Conclusion: To our knowledge, this is the first systematic review and meta-analysis that specifically evaluates the role of MOM on BPD. Our data indicate that MOM may reduce the incidence of BPD when used as an exclusive diet, but this result needs to be interpreted with caution. We did not find the same difference in analyses with other dosages of MOM. Further studies adequately powered to detect changes in BPD rates and that adjust for confounders are needed to confirm the beneficial effects of MOM on BPD.

Original languageEnglish
Article number224
Pages (from-to)1-9
Number of pages9
JournalFrontiers in pediatrics
Volume7
DOIs
Publication statusPublished - 6 Jun 2019

Keywords

  • mother's own milk
  • human milk
  • bronchopulmonary dysplasia
  • preterm formula
  • meta-analysis
  • systematic review
  • meta-regression
  • BIRTH-WEIGHT INFANTS
  • DONOR HUMAN-MILK
  • BREAST-MILK
  • PRETERM INFANTS
  • NECROTIZING ENTEROCOLITIS
  • PREMATURE-INFANTS
  • MATERNAL MILK
  • RANDOMIZED-TRIAL
  • GROWTH
  • OUTCOMES

Cite this