Molecular imaging of postprandial metabolism

Vera B. Schrauwen-Hinderling, Andre C. Carpentier*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

Disordered postprandial metabolism of energy substrates is one of the main defining features of prediabetes and contributes to the development of several chronic diseases associated with obesity, such as type 2 diabetes and cardiovascular diseases. Postprandial energy metabolism has been studied using classical isotopic tracer approaches that are limited by poor access to splanchnic metabolism and highly dynamic and complex exchanges of energy substrates involving multiple organs and systems. Advances in noninvasive molecular imaging modalities, such as PET and MRI/magnetic resonance spectroscopy (MRS), have recently allowed important advances in our understanding of postprandial energy metabolism in humans. The present review describes some of these recent advances, with particular focus on glucose and fatty acid metabolism in the postprandial state, and discusses current gaps in knowledge and new perspectives of application of PET and MRI/MRS for the investigation and treatment of human metabolic diseases.
Original languageEnglish
Pages (from-to)504-511
Number of pages8
JournalJournal of Applied Physiology
Volume124
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • dietary fat
  • glucose
  • energy metabolism
  • positron emission tomography
  • magnetic resonance imaging
  • magnetic resonance spectroscopy
  • BROWN ADIPOSE-TISSUE
  • POSITRON-EMISSION-TOMOGRAPHY
  • IMPAIRED GLUCOSE-TOLERANCE
  • FATTY-ACID-METABOLISM
  • SKELETAL-MUSCLE
  • F-18 FLUORODEOXYGLUCOSE
  • INSULIN STIMULATION
  • MYOCARDIAL UPTAKE
  • COLD-EXPOSURE
  • ADULT HUMANS

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