Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy.

F.A. van Nimwegen, J. Penders, E.E. Stobberingh, D.S. Postma, G.H. Koppelman, M. Kerkhof, N.E. Reijmerink, E. Dompeling, P.A. van den Brandt, I. Ferreira, M. Mommers, C. Thijs

Research output: Contribution to journalArticleAcademicpeer-review

158 Citations (Scopus)

Abstract

BACKGROUND: Both gastrointestinal microbiota composition and cesarean section have been linked to atopic manifestations. However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet. OBJECTIVES: We sought to investigate the relationship between microbiota composition, mode and place of delivery, and atopic manifestations. METHODS: The Child, Parent and Health: Lifestyle and Genetic Constitution Birth Cohort Study included data on birth characteristics, lifestyle factors, and atopic manifestations collected through repeated questionnaires from birth until age 7 years. Fecal samples were collected at age 1 month (n = 1176) to determine microbiota composition, and blood samples were collected at ages 1 (n = 921), 2 (n = 822), and 6 to 7 (n = 384) years to determine specific IgE levels. RESULTS: Colonization by Clostridium difficile at age 1 month was associated with wheeze and eczema throughout the first 6 to 7 years of life and with asthma at age 6 to 7 years. Vaginal home delivery compared with vaginal hospital delivery was associated with a decreased risk of eczema, sensitization to food allergens, and asthma. After stratification for parental history of atopy, the decreased risk of sensitization to food allergens (adjusted odds ratio, 0.52; 95% CI, 0.35-0.77) and asthma (adjusted odds ratio, 0.47; 95% CI, 0.29-0.77) among vaginally home-born infants was only found for children with atopic parents. Mediation analysis showed that the effects of mode and place of delivery on atopic outcomes were mediated by C difficile colonization. CONCLUSION: Mode and place of delivery affect the gastrointestinal microbiota composition, which subsequently influences the risk of atopic manifestations.
Original languageEnglish
Pages (from-to)948-955
Number of pages11
JournalJournal of Allergy and Clinical Immunology
Volume128
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Mode of delivery
  • cesarean section
  • hospital delivery
  • gastrointestinal microbiota composition
  • wheeze
  • eczema
  • asthma
  • atopy
  • mediation analysis
  • cohort study
  • KOALA study
  • KOALA BIRTH COHORT
  • INTESTINAL MICROFLORA
  • CESAREAN-SECTION
  • FECAL MICROFLORA
  • CHILDHOOD
  • ALLERGY
  • CHILDREN
  • INFANTS
  • RISK
  • GUT

Cite this

van Nimwegen, F.A. ; Penders, J. ; Stobberingh, E.E. ; Postma, D.S. ; Koppelman, G.H. ; Kerkhof, M. ; Reijmerink, N.E. ; Dompeling, E. ; van den Brandt, P.A. ; Ferreira, I. ; Mommers, M. ; Thijs, C. / Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. In: Journal of Allergy and Clinical Immunology. 2011 ; Vol. 128, No. 5. pp. 948-955.
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abstract = "BACKGROUND: Both gastrointestinal microbiota composition and cesarean section have been linked to atopic manifestations. However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet. OBJECTIVES: We sought to investigate the relationship between microbiota composition, mode and place of delivery, and atopic manifestations. METHODS: The Child, Parent and Health: Lifestyle and Genetic Constitution Birth Cohort Study included data on birth characteristics, lifestyle factors, and atopic manifestations collected through repeated questionnaires from birth until age 7 years. Fecal samples were collected at age 1 month (n = 1176) to determine microbiota composition, and blood samples were collected at ages 1 (n = 921), 2 (n = 822), and 6 to 7 (n = 384) years to determine specific IgE levels. RESULTS: Colonization by Clostridium difficile at age 1 month was associated with wheeze and eczema throughout the first 6 to 7 years of life and with asthma at age 6 to 7 years. Vaginal home delivery compared with vaginal hospital delivery was associated with a decreased risk of eczema, sensitization to food allergens, and asthma. After stratification for parental history of atopy, the decreased risk of sensitization to food allergens (adjusted odds ratio, 0.52; 95{\%} CI, 0.35-0.77) and asthma (adjusted odds ratio, 0.47; 95{\%} CI, 0.29-0.77) among vaginally home-born infants was only found for children with atopic parents. Mediation analysis showed that the effects of mode and place of delivery on atopic outcomes were mediated by C difficile colonization. CONCLUSION: Mode and place of delivery affect the gastrointestinal microbiota composition, which subsequently influences the risk of atopic manifestations.",
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Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. / van Nimwegen, F.A.; Penders, J.; Stobberingh, E.E.; Postma, D.S.; Koppelman, G.H.; Kerkhof, M.; Reijmerink, N.E.; Dompeling, E.; van den Brandt, P.A.; Ferreira, I.; Mommers, M.; Thijs, C.

In: Journal of Allergy and Clinical Immunology, Vol. 128, No. 5, 11.2011, p. 948-955.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy.

AU - van Nimwegen, F.A.

AU - Penders, J.

AU - Stobberingh, E.E.

AU - Postma, D.S.

AU - Koppelman, G.H.

AU - Kerkhof, M.

AU - Reijmerink, N.E.

AU - Dompeling, E.

AU - van den Brandt, P.A.

AU - Ferreira, I.

AU - Mommers, M.

AU - Thijs, C.

PY - 2011/11

Y1 - 2011/11

N2 - BACKGROUND: Both gastrointestinal microbiota composition and cesarean section have been linked to atopic manifestations. However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet. OBJECTIVES: We sought to investigate the relationship between microbiota composition, mode and place of delivery, and atopic manifestations. METHODS: The Child, Parent and Health: Lifestyle and Genetic Constitution Birth Cohort Study included data on birth characteristics, lifestyle factors, and atopic manifestations collected through repeated questionnaires from birth until age 7 years. Fecal samples were collected at age 1 month (n = 1176) to determine microbiota composition, and blood samples were collected at ages 1 (n = 921), 2 (n = 822), and 6 to 7 (n = 384) years to determine specific IgE levels. RESULTS: Colonization by Clostridium difficile at age 1 month was associated with wheeze and eczema throughout the first 6 to 7 years of life and with asthma at age 6 to 7 years. Vaginal home delivery compared with vaginal hospital delivery was associated with a decreased risk of eczema, sensitization to food allergens, and asthma. After stratification for parental history of atopy, the decreased risk of sensitization to food allergens (adjusted odds ratio, 0.52; 95% CI, 0.35-0.77) and asthma (adjusted odds ratio, 0.47; 95% CI, 0.29-0.77) among vaginally home-born infants was only found for children with atopic parents. Mediation analysis showed that the effects of mode and place of delivery on atopic outcomes were mediated by C difficile colonization. CONCLUSION: Mode and place of delivery affect the gastrointestinal microbiota composition, which subsequently influences the risk of atopic manifestations.

AB - BACKGROUND: Both gastrointestinal microbiota composition and cesarean section have been linked to atopic manifestations. However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet. OBJECTIVES: We sought to investigate the relationship between microbiota composition, mode and place of delivery, and atopic manifestations. METHODS: The Child, Parent and Health: Lifestyle and Genetic Constitution Birth Cohort Study included data on birth characteristics, lifestyle factors, and atopic manifestations collected through repeated questionnaires from birth until age 7 years. Fecal samples were collected at age 1 month (n = 1176) to determine microbiota composition, and blood samples were collected at ages 1 (n = 921), 2 (n = 822), and 6 to 7 (n = 384) years to determine specific IgE levels. RESULTS: Colonization by Clostridium difficile at age 1 month was associated with wheeze and eczema throughout the first 6 to 7 years of life and with asthma at age 6 to 7 years. Vaginal home delivery compared with vaginal hospital delivery was associated with a decreased risk of eczema, sensitization to food allergens, and asthma. After stratification for parental history of atopy, the decreased risk of sensitization to food allergens (adjusted odds ratio, 0.52; 95% CI, 0.35-0.77) and asthma (adjusted odds ratio, 0.47; 95% CI, 0.29-0.77) among vaginally home-born infants was only found for children with atopic parents. Mediation analysis showed that the effects of mode and place of delivery on atopic outcomes were mediated by C difficile colonization. CONCLUSION: Mode and place of delivery affect the gastrointestinal microbiota composition, which subsequently influences the risk of atopic manifestations.

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KW - cesarean section

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KW - cohort study

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KW - KOALA BIRTH COHORT

KW - INTESTINAL MICROFLORA

KW - CESAREAN-SECTION

KW - FECAL MICROFLORA

KW - CHILDHOOD

KW - ALLERGY

KW - CHILDREN

KW - INFANTS

KW - RISK

KW - GUT

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JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

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