Skin aging, scar formation and some types of eczema are associated with dysregulation of the intracellular water content of the epidermis. One of the main reasons for this is a disruption of the skin barrier function which subsequently leads to an increased Trans Epidermal Water Loss (TEWL). This often results in a dry, fragile, and itchy skin, requiring rehydration and restoration of the barrier function. Based on the currently available literature, there is no clear evidence about the most optimal treatment to achieve these goals and a myriad of indifferent creams are advised in (inter) national guidelines. Since 2005 a Medical Moisture Retention Cream (MMRC) Alhydran® is used in many health care settings worldwide for patients with various pathologies associated with an impaired barrier function of the skin. This article reports specifically about the available literature on MMRC and explains how its use may result in less itching and a better hydration status of the skin.