TY - JOUR
T1 - Micronuclei in human peripheral blood and bone marrow as genotoxicity markers
T2 - A systematic review and meta-analysis
AU - Antoniou, Evangelia E.
AU - Rooseboom, Martijn
AU - Kocabas, Neslihan A.
AU - North, Colin M.
AU - Zeegers, Maurice P.
N1 - Funding Information:
This project was funded by The Members of APA , a Cefic Sector Group, based in Brussels, Belgium.
Publisher Copyright:
© 2023 The Authors
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Can human peripheral blood cells be used as a surrogate for bone marrow cells, in evaluating the genotoxic effects of stressors? We searched the Pubmed/Medline and PubChem databases to identify publications relevant to this question. Micronucleus formation was the genotoxicity endpoint. Three publications comparing exposed vs. non-exposed individuals are included in this analysis; the exposures were to ethylene oxide or ionising radiation (atomic bomb, thorotrast, or radioiodine therapy). Information was extracted on the types of exposure, the numbers of participants, and the micronucleus frequencies. Relative differences (odds ratios) and absolute differences (risk differences) in the numbers of micronuclei between exposed and non-exposed persons were calculated separately for individual cell types (peripheral blood and bone marrow). Random effects meta-analyses for the relative differences in cell abnormalities were performed. The results showed very small differences in the frequencies of micronuclei between exposed and non-exposed individuals, as measured in either peripheral blood or bone marrow cell populations, on both absolute and relative scales. No definite conclusion concerning the relative sensitivities of bone marrow and peripheral blood cells can be made, based on these publications.
AB - Can human peripheral blood cells be used as a surrogate for bone marrow cells, in evaluating the genotoxic effects of stressors? We searched the Pubmed/Medline and PubChem databases to identify publications relevant to this question. Micronucleus formation was the genotoxicity endpoint. Three publications comparing exposed vs. non-exposed individuals are included in this analysis; the exposures were to ethylene oxide or ionising radiation (atomic bomb, thorotrast, or radioiodine therapy). Information was extracted on the types of exposure, the numbers of participants, and the micronucleus frequencies. Relative differences (odds ratios) and absolute differences (risk differences) in the numbers of micronuclei between exposed and non-exposed persons were calculated separately for individual cell types (peripheral blood and bone marrow). Random effects meta-analyses for the relative differences in cell abnormalities were performed. The results showed very small differences in the frequencies of micronuclei between exposed and non-exposed individuals, as measured in either peripheral blood or bone marrow cell populations, on both absolute and relative scales. No definite conclusion concerning the relative sensitivities of bone marrow and peripheral blood cells can be made, based on these publications.
KW - Bone marrow
KW - Genotoxicity
KW - Meta-analysis
KW - Micronuclei
KW - Peripheral blood
KW - Systematic review
U2 - 10.1016/j.mrgentox.2023.503689
DO - 10.1016/j.mrgentox.2023.503689
M3 - (Systematic) Review article
SN - 1383-5718
VL - 891
JO - Mutation Research-Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis
IS - 1
M1 - 503689
ER -