@inbook{a34db69d05924d14baea8f555356be8e,
title = "Metabolomics in Nutritional Metabolism, Obesity, and Diabetes: Metabolomics in Nutritional Metabolism, Obesity, and Diabetes",
abstract = "This chapter reviews a series of metabolomic studies carried out in previous years on the utility and application of nuclear magnetic resonance (NMR)-based metabolomics in an attempt to understand pathophysiological mechanisms in obesity and diabetes. The first part focuses on several methodological concerns that are critical to blood plasma 1H NMR experimental design in clinical, biobank and multicentre research settings. Variations in sample collection, preparation and storage within the field of clinical metabolomics might hamper the effective implementation of 1H NMR spectroscopy. We describe and comment on specific precautions or improvements that should be taken into account at each experimental stage when performing 1H NMR-based metabolomics research on plasma samples. Next, we discuss the application of 1H NMR-metabolite phenotyping in the context of childhood obesity and diabetes. NMR-based metabolomics offers a complementary tool to traditional screening in order to more accurately and comprehensively identify metabolic risk profiles. In the end, more targeted and effective screening and intervention strategies for obesity and early-onset diabetes can be developed.",
author = "L. Bervoets and P. Adriaensens",
note = "Funding Information: The authors thank all the volunteers who participated in these studies. They also gratefully acknowledge colleagues at Hasselt University, Jessa Hospital and University Biobank Limburg for their contributions. This work was supported by a grant from ZonMW/JPI HDHL Intestinal Microbiomics (grant 50-52905-98-599) and by Hasselt University and the Research Foundation Flanders (FWO Vlaanderen; Hercules project AUHL/15/2-GOH3816N). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",
year = "2021",
month = jan,
day = "1",
doi = "10.1039/9781839160608-00210",
language = "English",
isbn = "978-1-78801-557-8",
series = "Food Chemistry, Function and Analysis",
publisher = "Royal Society of Chemistry",
editor = "Zhiyong Cheng",
booktitle = "Nutritional Signaling Pathway Activities in Obesity and Diabetes",
address = "United Kingdom",
edition = "24",
}