Metabolic models

Jean Marc Schwartz; Zita Soons

doi:10.1016/B978-0-12-809633-8.20255-0

Metabolic models

Jean Marc Schwartz, Zita Soons

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Metabolic networks are generally better known than other types of cellular networks, and they are therefore well suited for the development of computational models. A range of different techniques can be used to model systems of metabolic reactions, from kinetic methods which seek to represent the exact dynamics of fluxes over time, to constraint-based and structural methods which only consider steady state situations. Altogether these methods have led to important progress in our understanding of cellular functions and how they are regulated by exchanges with the extracellular environment.

Original language	English
Title of host publication	Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics
Publisher	Elsevier
Pages	438-444
Number of pages	7
Volume	1-3
ISBN (Electronic)	9780128114322
ISBN (Print)	9780128114148
DOIs	https://doi.org/10.1016/B978-0-12-809633-8.20255-0
Publication status	Published - 1 Jan 2018

Keywords

Elementary mode
Enzyme kinetics
Metabolic flux
Metabolic network
Structural flux

Access to Document

10.1016/B978-0-12-809633-8.20255-0

Cite this

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AU - Soons, Zita

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AB - Metabolic networks are generally better known than other types of cellular networks, and they are therefore well suited for the development of computational models. A range of different techniques can be used to model systems of metabolic reactions, from kinetic methods which seek to represent the exact dynamics of fluxes over time, to constraint-based and structural methods which only consider steady state situations. Altogether these methods have led to important progress in our understanding of cellular functions and how they are regulated by exchanges with the extracellular environment.

KW - Elementary mode

KW - Enzyme kinetics

KW - Metabolic flux

KW - Metabolic network

KW - Structural flux

U2 - 10.1016/B978-0-12-809633-8.20255-0

DO - 10.1016/B978-0-12-809633-8.20255-0

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EP - 444

BT - Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics

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