Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder

Murat Ilhan Atagun*, Marjan Drukker, Mei Hua Hall, Ilkay Keles Altun, Safiye Zeynep Tatli, Sinan Guloksuz, Jim van Os, Therese van Amelsvoort

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

The ability of the brain to reduce the amount of trivial or redundant sensory inputs is called gating function. Dysfunction of sensory gating may lead to cognitive fragmentation and poor real-world functioning. The auditory dual-click paradigm is a pertinent neurophysiological measure of sensory gating function. This meta-analysis aimed to examine the subcomponents of abnormal P50 waveforms in bipolar disorder and schizophrenia to assess P50 sensory gating deficits and examine effects of diagnoses, illness states (first-episode psychosis vs. schizophrenia, remission vs. episodes in bipolar disorder), and treatment status (medication -free vs. medicated). Literature search of PubMed between Jan 1st 1980 and March 31st 2019 identified 2091 records for schizo-phrenia, 362 for bipolar disorder. 115 studies in schizophrenia (4932 patients), 16 in bipolar disorder (975 patients) and 10 in first-degree relatives (848 subjects) met the inclusion criteria. P50 sensory gating ratio (S2/S1) and S1-S2 difference were significantly altered in schizophrenia, bipolar disorder and their first-degree relatives. First-episode psychosis did not differ from schizophrenia, however episodes altered P50 sensory gating in bipolar disorder. Medications improve P50 sensory gating alterations in schizophrenia significantly and at trend level in bipolar disorder. Future studies should examine longitudinal course of P50 sensory gating in schizophrenia and bipolar disorder.

Original languageEnglish
Article number111078
Number of pages15
JournalPsychiatry Research-Neuroimaging
Volume300
DOIs
Publication statusPublished - 30 Jun 2020

Keywords

  • EEG
  • Sensory gating
  • Bipolar disorder
  • Schizophrenia
  • INFORMATION-PROCESSING DEFICITS
  • SPECTRAL FREQUENCY ANALYSES
  • PREPULSE INHIBITION
  • 1ST-EPISODE SCHIZOPHRENIA
  • SUPPRESSION DEFICIT
  • EVOKED-RESPONSE
  • NEUROPSYCHOLOGICAL DYSFUNCTION
  • CATECHOLAMINE METABOLISM
  • ATYPICAL ANTIPSYCHOTICS
  • HIPPOCAMPAL VOLUME

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