Memory deficits in the transgenic rat model of Huntington's disease

Dagmar H. Zeef*, Nick P. van Goethem, Rinske Vlamings, Frederic Schaper, Ali Jahanshahi, Sarah Hescham, Stephan von Hoersten, Jos Prickaerts, Yasin Temel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)

Abstract

Memory deficits are common in patients with Huntington's disease (HD) and have a substantial impact on the quality of life of patients and their relatives. A good model resembling the human memory deficits is needed for research purposes. In this study we investigated the memory function of the transgenic rat model of Huntington's disease (tgHD) in the object location (OLT) and the object recognition task (ORT). Several studies have shown that the recent developed tgHD rat model resembles the human phenotype of HD. Impairments of spatial and object recognition memory in the OLT and ORT, however, have to our knowledge not yet been reported in this transgenic model. Our findings show that in both early and late stages of the disease the tgHD rats have clear deficits for both visuospatial and visual object memory. Since HD patients are known to be impaired in both types of memory, these results confirm the validity of this tgHD rat as a model for the human HD phenotype.
Original languageEnglish
Pages (from-to)194-198
JournalBehavioural Brain Research
Volume227
Issue number1
DOIs
Publication statusPublished - 1 Feb 2012

Keywords

  • Huntington's disease
  • Transgenic rat model
  • Memory deficits
  • Object recognition memory
  • Object location memory

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