Mass spectrometry imaging of metabolites

Benjamin Balluff, Liam A. McDonnell*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Mass spectrometry imaging (MSI) is a technique which is gaining increasing interest in biomedical research due to its capacity to visualize molecules in tissues. First applied to the field of clinical proteomics, its potential for metabolite imaging in biomedical studies is now being recognized. Here we describe how to set up experiments for mass spectrometry imaging of metabolites in clinical tissues and how to tackle most of the obstacles in the subsequent analysis of the data.
Original languageEnglish
Title of host publicationClinical Metabolomics
Subtitle of host publicationMethods and Protocols
EditorsMartin Giera
PublisherHumana Press
Pages345-357
Number of pages13
Volume1730
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

SeriesMethods in Molecular Biology
Volume1730
ISSN1064-3745

Keywords

  • Biomarker discovery
  • Data analysis
  • Mass spectrometry imaging
  • Tissue metabolomics

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