Mapping the location of local and regional recurrences according to breast cancer surgery and radiation therapy: Results from EORTC 22922/ 10925

Orit Kaidar-Person*, Peggy Giasafaki, Liesbeth Boersma, Peter De Brouwer, Caroline Weltens, Carine Kirkove, Karine Peignaux-Casasnovas, Volker Budach, Femke van der Leij, Ernest Vonk, Nicola Weidner, Sofia Rivera, Geertjan van Tienhoven, Alain Fourquet, Georges Noel, Mariacarla Valli, Matthias Guckenberger, Eveline Koiter, Severine Racadot, Roxolyana Abdah-BortnyakHarry Bartelink, Henk Struikmans, Catherine Fortpied, Philip M. Poortmans, EORTC Radiation Oncology and Breast Cancer Groups

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The purpose of this study is to evaluate the influence of the extent of surgery and radiation therapy (RT) on the rates and sites of local (LR) and regional recurrences (RR) in the EORTC 22922/10925 trial. Patients and methods: All data were extracted from the trial's individual patients' case report forms (CRF) and analysed with a median follow-up of 15.7 years. Cumulative incidence curves were produced for LR and RR accounting for competing risks: an exploratory analysis of the effect of the extent of surgical and radiation treatments on LR rate was conducted using the Fine & Gray model accounting for competing risks and adjusted for baseline patient and disease characteristics. The significance level was set at 5%, 2-sided. Frequency tables were used to describe the spatial location of LR and RR.Results: Out of 4004 patients included in the trial, 282 (7%) patients experienced LR and 165 (4.1%) RR, respectively. Cumulative incidence rate of LR at 15 years was lower after mastectomy (3.1%) compared to BCS + RT (7.3%) (F&G: HR (Hazard Ratio) = 0.421, 95%CI = 0.282-0.628, p-value < 0.0001). LR were sim-ilar up to 3 years for both mastectomy and BCS but continued to occur at a steady rate for BCS + RT, only. The spatial location of the recurrence was related to the locoregional therapy applied and the absolute gain of RT correlated to stage of disease and extent of surgery.Conclusions: The extent of locoregional therapies impacts significantly on LR and RR rates and spatial location.(c) 2023 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 185 (2023) 109698
Original languageEnglish
Article number109698
Number of pages7
JournalRadiotherapy and Oncology
Issue number1
Early online date1 May 2023
Publication statusPublished - 1 Aug 2023


  • Radiotherapy
  • Breast cancer
  • Local recurrences
  • Loco -regional recurrences


Dive into the research topics of 'Mapping the location of local and regional recurrences according to breast cancer surgery and radiation therapy: Results from EORTC 22922/ 10925'. Together they form a unique fingerprint.

Cite this