MALDI Guided SpatialOMx (R) Uncovers Proteomic Profiles in Tumor Subpopulations of Breast Cancer

Janina Oetjen*, Romano Hebeler, Frederic Dewez, Corinna Henkel, Benjamin Balluff, Ron Heeren

*Corresponding author for this work

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The timsTOF fleX system bridges a current gap by providing MALDI Imaging and in-depth proteomics analysis in just one instrument. The instrument offers all benefits of a timsTOF Pro for time-efficient and sensitive proteomics, combined with a high-resolution MALDI source and stage. Using PASEF technology, it is possible to retrieve high protein ID rates with small sample amounts. Here we present the new SpatialOMx (R) workflow to identify distinct proteomic profiles for different tumor subpopulations in breast cancer as an example for this powerful approach.

Original languageEnglish
Pages (from-to)528-530
Number of pages3
JournalLc Gc North America
Issue number9
Publication statusPublished - Sept 2020

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