TY - JOUR
T1 - Lung Cancer in the Oldest Old
T2 - A Nation-Wide Study in The Netherlands
AU - Schulkes, Karlijn J. G.
AU - Pouw, Carin A. M.
AU - Driessen, Elisabeth J. M.
AU - van Elden, Leontine J. R.
AU - van den Bos, Frederiek
AU - Janssen-Heijnen, Maryska L. G.
AU - Lammers, Jan-Willem J.
AU - Hamaker, Marije E.
PY - 2017/10
Y1 - 2017/10
N2 - Introduction An important step in improving research and care for the oldest patients with lung cancer is analyzing current data regarding diagnostic work-up, treatment choices, and survival.Methods We analyzed data on lung cancer from the Netherlands Cancer Registry (NCR-IKNL) regarding diagnostic work-up, treatment, and survival in different age categories; the oldest old (>= 85 years of age) versus those aged 71-84 (elderly) and those agedResults 47,951 patients were included in the 2010-2014 NCR database. 2196 (5%) patients were aged >= 85 years. Histological diagnosis was obtained significantly less often in the oldest old (38%, p <0.001), and less standard treatment regimen was given (8%, p <0.001) compared to elderly and younger patients. 67% of the oldest old received best supportive care only versus 38% of the elderly and 20% of the younger patients (p <0.001). For the oldest old receiving standard treatment, survival rates were similar in comparison with the elderly patients. In the oldest old, no survival differences were found when comparing standard or adjusted regimens for stage I and IV NSCLC; for stage III, oldest old receiving standard treatment had longer survival. No oldest old patients with stage II received standard treatment.Conclusion Clinicians make limited use of diagnostics and invasive treatment in the oldest old; however, selected oldest old patients experienced similar survival rates as the elderly when receiving some form of anticancer therapy (standard or adjusted). More research is needed to further develop individualized treatment algorithms.
AB - Introduction An important step in improving research and care for the oldest patients with lung cancer is analyzing current data regarding diagnostic work-up, treatment choices, and survival.Methods We analyzed data on lung cancer from the Netherlands Cancer Registry (NCR-IKNL) regarding diagnostic work-up, treatment, and survival in different age categories; the oldest old (>= 85 years of age) versus those aged 71-84 (elderly) and those agedResults 47,951 patients were included in the 2010-2014 NCR database. 2196 (5%) patients were aged >= 85 years. Histological diagnosis was obtained significantly less often in the oldest old (38%, p <0.001), and less standard treatment regimen was given (8%, p <0.001) compared to elderly and younger patients. 67% of the oldest old received best supportive care only versus 38% of the elderly and 20% of the younger patients (p <0.001). For the oldest old receiving standard treatment, survival rates were similar in comparison with the elderly patients. In the oldest old, no survival differences were found when comparing standard or adjusted regimens for stage I and IV NSCLC; for stage III, oldest old receiving standard treatment had longer survival. No oldest old patients with stage II received standard treatment.Conclusion Clinicians make limited use of diagnostics and invasive treatment in the oldest old; however, selected oldest old patients experienced similar survival rates as the elderly when receiving some form of anticancer therapy (standard or adjusted). More research is needed to further develop individualized treatment algorithms.
KW - Frail
KW - Geriatric
KW - IKNL
KW - NCR
KW - NKR
KW - Pulmonary malignancies
KW - COMPREHENSIVE GERIATRIC ASSESSMENT
KW - ELDERLY-PATIENTS
KW - CLINICAL-PRACTICE
KW - DECISION-MAKING
KW - ONCOLOGY
KW - OCTOGENARIANS
KW - CHEMOTHERAPY
KW - FACILITATORS
KW - CHALLENGES
KW - SURVIVAL
U2 - 10.1007/s00408-017-0026-1
DO - 10.1007/s00408-017-0026-1
M3 - Article
C2 - 28631153
SN - 0341-2040
VL - 195
SP - 627
EP - 634
JO - Lung
JF - Lung
IS - 5
ER -