Abstract
BACKGROUND: Low skeletal muscle radiation attenuation (SM-RA) is indicative of myosteatosis and diminished muscle function. It is predictive of poor outcome following oncological surgery in several cancer types. Postoperative pneumonia is a known risk factor for increased postoperative mortality. We hypothesized that low SM-RA of the respiratory muscles at the 4th thoracic-vertebra (T4) is associated with postoperative pneumonia following liver surgery.
METHODS: Postoperative pneumonia was identified using prospective infection control data. Computed tomography body composition analysis was performed at the L3-and T4 level to determine SM-RA. Body composition variables were corrected for confounders and related to postoperative pneumonia and admission time by multivariable logistic regression.
RESULTS: Body composition analysis of 180 patients was performed. Twenty-one patients developed postoperative pneumonia (11.6%). Multivariable analysis showed that low T4 SM-RA as well as low L3 SM-RA were significantly associated with postoperative pneumonia (OR 3.65, 95% CI 1.41-9.49, p < 0.01) and (OR 3.22, 95% CI 1.20-8.61, p = 0.02, respectively).
CONCLUSION: Low SM-RA at either the L3-or T4-level is associated with a higher risk of postoperative pneumonia following CLRM resection.
Original language | English |
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Pages (from-to) | 1011-1019 |
Number of pages | 9 |
Journal | HPB |
Volume | 22 |
Issue number | 7 |
Early online date | 15 Nov 2019 |
DOIs | |
Publication status | Published - Jul 2020 |
Keywords
- BODY-COMPOSITION
- COMPUTED-TOMOGRAPHY
- HEALTH
- MORTALITY
- PREDICTOR
- PULMONARY COMPLICATIONS
- SARCOPENIC OBESITY
- SKELETAL-MUSCLE
- SURGERY
- VISCERAL ADIPOSITY
- CANCER