Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

Talita Honorato; Annemieke Hoek; Anna Karina Henningsen; Anja Pinborg; Ojvind Lidegaard; Thea Mooij; Floor van Leeuwen; Jolande Land; Henk Groen; Maaike Haadsma; A. W. van den Belt-Dusebout; C. W. Burger; B. J. Cohlen; C. B. Lambalk; D. D.M. Braat; E. J.P. van Santbrink; L. A.J. van der Westerlaken; J. M.J. Smeenk; M. Goddijn; M. Kortman; M. M. van Rumste; R. J.T. Van Golde; R. Schats; OMEGA Project Group

doi:10.1016/j.rbmo.2017.08.022

Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

Talita Honorato^*, Annemieke Hoek, Anna Karina Henningsen, Anja Pinborg, Ojvind Lidegaard, Thea Mooij, Floor van Leeuwen, Jolande Land, Henk Groen, Maaike Haadsma, A. W. van den Belt-Dusebout, C. W. Burger, B. J. Cohlen, C. B. Lambalk, D. D.M. Braat, E. J.P. van Santbrink, L. A.J. van der Westerlaken, J. M.J. Smeenk, M. Goddijn, M. KortmanM. M. van Rumste, R. J.T. Van Golde, R. Schats, OMEGA Project Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

Original language	English
Pages (from-to)	685-692
Number of pages	8
Journal	Reproductive Biomedicine Online
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.rbmo.2017.08.022
Publication status	Published - 1 Dec 2017

Keywords

IVF
Oocyte
Ovarian reserve
Trisomy

Access to Document

10.1016/j.rbmo.2017.08.022

Cite this

Honorato, T., Hoek, A., Henningsen, A. K., Pinborg, A., Lidegaard, O., Mooij, T., van Leeuwen, F., Land, J., Groen, H., Haadsma, M., van den Belt-Dusebout, A. W., Burger, C. W., Cohlen, B. J., Lambalk, C. B., Braat, D. D. M., van Santbrink, E. J. P., van der Westerlaken, L. A. J., Smeenk, J. M. J., Goddijn, M., ... OMEGA Project Group (2017). Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy. Reproductive Biomedicine Online, 35(6), 685-692. https://doi.org/10.1016/j.rbmo.2017.08.022

@article{b8599ca56beb46a6ba2ddf9e571869c3,

title = "Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy",

abstract = "A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.",

keywords = "IVF, Oocyte, Ovarian reserve, Trisomy",

author = "Talita Honorato and Annemieke Hoek and Henningsen, {Anna Karina} and Anja Pinborg and Ojvind Lidegaard and Thea Mooij and {van Leeuwen}, Floor and Jolande Land and Henk Groen and Maaike Haadsma and {van den Belt-Dusebout}, {A. W.} and Burger, {C. W.} and Cohlen, {B. J.} and Lambalk, {C. B.} and Braat, {D. D.M.} and {van Santbrink}, {E. J.P.} and {van der Westerlaken}, {L. A.J.} and Smeenk, {J. M.J.} and M. Goddijn and M. Kortman and {van Rumste}, {M. M.} and {Van Golde}, {R. J.T.} and R. Schats and {OMEGA Project Group}",

note = "Publisher Copyright: {\textcopyright} 2017 Reproductive Healthcare Ltd.",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.rbmo.2017.08.022",

language = "English",

volume = "35",

pages = "685--692",

journal = "Reproductive Biomedicine Online",

issn = "1472-6483",

publisher = "ELSEVIER SCI LTD",

number = "6",

}

Honorato, T, Hoek, A, Henningsen, AK, Pinborg, A, Lidegaard, O, Mooij, T, van Leeuwen, F, Land, J, Groen, H, Haadsma, M, van den Belt-Dusebout, AW, Burger, CW, Cohlen, BJ, Lambalk, CB, Braat, DDM, van Santbrink, EJP, van der Westerlaken, LAJ, Smeenk, JMJ, Goddijn, M, Kortman, M, van Rumste, MM, Van Golde, RJT, Schats, R & OMEGA Project Group 2017, 'Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy', Reproductive Biomedicine Online, vol. 35, no. 6, pp. 685-692. https://doi.org/10.1016/j.rbmo.2017.08.022

TY - JOUR

T1 - Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy

AU - Honorato, Talita

AU - Hoek, Annemieke

AU - Henningsen, Anna Karina

AU - Pinborg, Anja

AU - Lidegaard, Ojvind

AU - Mooij, Thea

AU - van Leeuwen, Floor

AU - Land, Jolande

AU - Groen, Henk

AU - Haadsma, Maaike

AU - van den Belt-Dusebout, A. W.

AU - Burger, C. W.

AU - Cohlen, B. J.

AU - Lambalk, C. B.

AU - Braat, D. D.M.

AU - van Santbrink, E. J.P.

AU - van der Westerlaken, L. A.J.

AU - Smeenk, J. M.J.

AU - Goddijn, M.

AU - Kortman, M.

AU - van Rumste, M. M.

AU - Van Golde, R. J.T.

AU - Schats, R.

AU - OMEGA Project Group

PY - 2017/12/1

Y1 - 2017/12/1

N2 - A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

AB - A low number of antral follicles may result in the selection of suboptimal oocytes that are prone to meiotic errors. The aim of this case-control study was to evaluate women receiving IVF treatment with low oocyte yield (defined as three or fewer oocytes retrieved after ovarian stimulation) who are at an increased risk of a trisomic pregnancy. Data were obtained from Danish and Dutch medical registries between 1983 and 2011. Analyses were carried out in 105 cases and 442 controls matched by age and year of IVF treatment. Cases were women with a trisomic pregnancy (trisomies 13, 18 or 21) resulting from fresh IVF treatment and confirmed by karyotyping. Cases were included regardless of pregnancy outcome. Controls were women with a live born child without a trisomy, resulting from fresh IVF treatment. Low oocyte yield was observed in 6.6% (29/440) of the women, of which 8.4% (7/83) were cases and 6.2% (22/357) controls. Low oocyte yield in IVF treatment was not associated with a higher risk of trisomic pregnancy (OR 1.43, 95% CI 0.64 to 3.19). Stratification for female age, adjustment for history of ovarian surgery, and gonadotrophin-releasing hormone protocol used did not change the results.

KW - IVF

KW - Oocyte

KW - Ovarian reserve

KW - Trisomy

U2 - 10.1016/j.rbmo.2017.08.022

DO - 10.1016/j.rbmo.2017.08.022

M3 - Article

SN - 1472-6483

VL - 35

SP - 685

EP - 692

JO - Reproductive Biomedicine Online

JF - Reproductive Biomedicine Online

IS - 6

ER -