Low-Level Laser Therapy and Topical Medications for Treating Aphthous Ulcers: A Systematic Review

Mohammed Khaleel Ahmed, Mohammed Jafer, Maryam Nayeem, Ibtisam Hussain Moafa, Mir Furruq Ali Quadri, Hema Gopalaiah, Mir Faeq Ali Quadri*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


Objective: The study compares low-level laser therapy with topical medications for treating aphthous ulcers.

Methods: A search of articles in this systematic review was completed in six databases. Treatment and comparative groups comprised of patients subjected to laser therapy and topical medications, respectively. Two different treatment outcomes were considered; pain and size of the lesion. Risk of bias was assessed using the Revised Cochrane risk-of-bias tool for randomized trials.

Results: From 109 articles, five randomized control trials fulfilled the selection criteria. The overall sample comprised of 98 males and 232 females, with a mean age of 32.4 years. The laser therapies in each included study had different active media and varying wavelengths. Topical medication used in the comparative group were triamcinolone acetonide, amlexanox, granofurin, and solcoseryl. Findings showed that patients who reported lower pain and decreased aphthous ulcer lesions were more in the laser therapy group than in the topical medication group.

Conclusion: Low-level laser therapy was better in treating aphthous ulcer lesions in comparison to topical medications, and all laser wavelengths in the included reports were seen to be effective. However, the results should be interpreted with caution, because no study demonstrated low-risk of bias in all the assessed domains.

Original languageEnglish
Pages (from-to)1595-1605
Number of pages11
JournalJournal of Multidisciplinary Healthcare
Publication statusPublished - 2020


  • aphthous ulcer
  • recurrent aphthous stomatitis
  • low-level laser therapy
  • systematic review
  • evidence-based practice
  • PAIN
  • OMEGA-3


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