TY - JOUR
T1 - Long-term effect of asthma on the development of obesity among adults
T2 - an international cohort study, ECRHS
AU - Moitra, Subhabrata
AU - Carsin, Anne-Elie
AU - Abramson, Michael J
AU - Accordini, Simone
AU - Amaral, Andre F S
AU - Anto, Josep
AU - Bono, Roberto
AU - Casas Ruiz, Lidia
AU - Cerveri, Isa
AU - Chatzi, Leda
AU - Demoly, Pascal
AU - Dorado-Arenas, Sandra
AU - Forsberg, Bertil
AU - Gilliland, Frank
AU - Gislason, Thorarinn
AU - Gullón, Jose A
AU - Heinrich, Joachim
AU - Holm, Mathias
AU - Janson, Christer
AU - Jogi, Rain
AU - Gómez Real, Francisco
AU - Jarvis, Debbie
AU - Leynaert, Bénédicte
AU - Nowak, Dennis
AU - Probst-Hensch, Nicole
AU - Sánchez-Ramos, José Luis
AU - Raherison-Semjen, Chantal
AU - Siroux, Valerie
AU - Guerra, Stefano
AU - Kogevinas, Manolis
AU - Garcia-Aymerich, Judith
N1 - © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: Obesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults.METHODS: We used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m2) individuals at visit t. The relative risk (RR) of obesity at t+1 associated with asthma at t was estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity.RESULTS: We included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II-III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association.CONCLUSION: This is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids.
AB - INTRODUCTION: Obesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults.METHODS: We used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m2) individuals at visit t. The relative risk (RR) of obesity at t+1 associated with asthma at t was estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity.RESULTS: We included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II-III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association.CONCLUSION: This is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids.
KW - ASSOCIATION
KW - Asthma
KW - Asthma Epidemiology
KW - BODY-MASS INDEX
KW - COMMUNITY
KW - Clinical Epidemiology
KW - GENERAL-PRACTITIONERS
KW - LUNG-FUNCTION
KW - NATIONAL-HEALTH
KW - NUTRITION EXAMINATION
KW - PHYSICAL-ACTIVITY
KW - SMOKING-CESSATION
KW - WEIGHT-GAIN
U2 - 10.1136/thoraxjnl-2021-217867
DO - 10.1136/thoraxjnl-2021-217867
M3 - Article
C2 - 35477559
SN - 0040-6376
VL - 78
SP - 128
EP - 135
JO - Thorax
JF - Thorax
IS - 2
ER -