Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation

I. Cuijpers, A.P. Papageorgiou, P. Carai, M. Herwig, A. Mugge, T. Klein, N. Hamdani, E.A.V. Jones, S. Heymans

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)729-741
Number of pages13
JournalJournal of Cellular and Molecular Medicine
Volume25
Issue number2
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • cardiac dysfunction
  • cardiomyocyte passive stiffness
  • diastolic dysfunction
  • dipeptidyl peptidase-4
  • heart-failure
  • inhibitor linagliptin
  • left ventricular stiffening
  • linagliptin
  • metabolic syndrome
  • muscle
  • myocardial titin
  • pressure
  • protein
  • stiffness
  • titin
  • INHIBITOR LINAGLIPTIN
  • PROTEIN
  • MUSCLE
  • MYOCARDIAL TITIN
  • PRESSURE
  • HEART-FAILURE
  • CARDIAC DYSFUNCTION
  • DIASTOLIC DYSFUNCTION
  • DIPEPTIDYL PEPTIDASE-4
  • STIFFNESS

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