Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task

Ilenia Paparella; Islay Campbell; Roya Sharifpour; Elise Beckers; Alexandre Berger; Jose Fermin Balda Aizpurua; Ekaterina Koshmanova; Nasrin Mortazavi; Puneet Talwar; Christian Degueldre; Laurent Lamalle; Siya Sherif; Christophe Phillips; Pierre Maquet; Gilles Vandewalle

doi:10.1038/s42003-023-05337-5

Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task

Ilenia Paparella, Islay Campbell, Roya Sharifpour, Elise Beckers, Alexandre Berger, Jose Fermin Balda Aizpurua, Ekaterina Koshmanova, Nasrin Mortazavi, Puneet Talwar, Christian Degueldre, Laurent Lamalle, Siya Sherif, Christophe Phillips, Pierre Maquet, Gilles Vandewalle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to trigger this stimulating effect is not established. Here we record the brain activity of 19 healthy young participants (24.05±2.63; 12 women) while they complete an auditory attentional task in darkness or under an active (blue-enriched) or a control (orange) light, in an ultra-high-field 7 Tesla MRI scanner. We test if light modulates the effective connectivity between an area of the posterior associative thalamus, encompassing the pulvinar, and the intraparietal sulcus (IPS), key areas in the regulation of attention. We find that only the blue-enriched light strengthens the connection from the posterior thalamus to the IPS. To the best of our knowledge, our results provide the first empirical data supporting that blue wavelength light affects ongoing non-visual cognitive activity by modulating task-dependent information flow from subcortical to cortical areas.

Original language	English
Article number	945
Number of pages	10
Journal	Communications Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s42003-023-05337-5
Publication status	Published - 16 Sept 2023

Keywords

Humans
Female
Thalamus/diagnostic imaging
Cross Reactions
Healthy Volunteers
Light

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10.1038/s42003-023-05337-5Licence: CC BY

Cite this

Paparella, I., Campbell, I., Sharifpour, R., Beckers, E., Berger, A., Aizpurua, J. F. B., Koshmanova, E., Mortazavi, N., Talwar, P., Degueldre, C., Lamalle, L., Sherif, S., Phillips, C., Maquet, P., & Vandewalle, G. (2023). Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task. Communications Biology, 6(1), Article 945. https://doi.org/10.1038/s42003-023-05337-5

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abstract = "Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to trigger this stimulating effect is not established. Here we record the brain activity of 19 healthy young participants (24.05±2.63; 12 women) while they complete an auditory attentional task in darkness or under an active (blue-enriched) or a control (orange) light, in an ultra-high-field 7 Tesla MRI scanner. We test if light modulates the effective connectivity between an area of the posterior associative thalamus, encompassing the pulvinar, and the intraparietal sulcus (IPS), key areas in the regulation of attention. We find that only the blue-enriched light strengthens the connection from the posterior thalamus to the IPS. To the best of our knowledge, our results provide the first empirical data supporting that blue wavelength light affects ongoing non-visual cognitive activity by modulating task-dependent information flow from subcortical to cortical areas.",

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author = "Ilenia Paparella and Islay Campbell and Roya Sharifpour and Elise Beckers and Alexandre Berger and Aizpurua, {Jose Fermin Balda} and Ekaterina Koshmanova and Nasrin Mortazavi and Puneet Talwar and Christian Degueldre and Laurent Lamalle and Siya Sherif and Christophe Phillips and Pierre Maquet and Gilles Vandewalle",

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Paparella, I, Campbell, I, Sharifpour, R, Beckers, E, Berger, A, Aizpurua, JFB, Koshmanova, E, Mortazavi, N, Talwar, P, Degueldre, C, Lamalle, L, Sherif, S, Phillips, C, Maquet, P & Vandewalle, G 2023, 'Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task', Communications Biology, vol. 6, no. 1, 945. https://doi.org/10.1038/s42003-023-05337-5

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AU - Paparella, Ilenia

AU - Campbell, Islay

AU - Sharifpour, Roya

AU - Beckers, Elise

AU - Berger, Alexandre

AU - Aizpurua, Jose Fermin Balda

AU - Koshmanova, Ekaterina

AU - Mortazavi, Nasrin

AU - Talwar, Puneet

AU - Degueldre, Christian

AU - Lamalle, Laurent

AU - Sherif, Siya

AU - Phillips, Christophe

AU - Maquet, Pierre

AU - Vandewalle, Gilles

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Y1 - 2023/9/16

N2 - Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to trigger this stimulating effect is not established. Here we record the brain activity of 19 healthy young participants (24.05±2.63; 12 women) while they complete an auditory attentional task in darkness or under an active (blue-enriched) or a control (orange) light, in an ultra-high-field 7 Tesla MRI scanner. We test if light modulates the effective connectivity between an area of the posterior associative thalamus, encompassing the pulvinar, and the intraparietal sulcus (IPS), key areas in the regulation of attention. We find that only the blue-enriched light strengthens the connection from the posterior thalamus to the IPS. To the best of our knowledge, our results provide the first empirical data supporting that blue wavelength light affects ongoing non-visual cognitive activity by modulating task-dependent information flow from subcortical to cortical areas.

AB - Exposure to blue wavelength light stimulates alertness and performance by modulating a widespread set of task-dependent cortical and subcortical areas. How light affects the crosstalk between brain areas to trigger this stimulating effect is not established. Here we record the brain activity of 19 healthy young participants (24.05±2.63; 12 women) while they complete an auditory attentional task in darkness or under an active (blue-enriched) or a control (orange) light, in an ultra-high-field 7 Tesla MRI scanner. We test if light modulates the effective connectivity between an area of the posterior associative thalamus, encompassing the pulvinar, and the intraparietal sulcus (IPS), key areas in the regulation of attention. We find that only the blue-enriched light strengthens the connection from the posterior thalamus to the IPS. To the best of our knowledge, our results provide the first empirical data supporting that blue wavelength light affects ongoing non-visual cognitive activity by modulating task-dependent information flow from subcortical to cortical areas.

KW - Humans

KW - Female

KW - Thalamus/diagnostic imaging

KW - Cross Reactions

KW - Healthy Volunteers

KW - Light

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